PMID- 23688318
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140520
LR  - 20211021
IS  - 1476-9255 (Print)
IS  - 1476-9255 (Electronic)
IS  - 1476-9255 (Linking)
VI  - 10
DP  - 2013
TI  - Transient expansion of activated CD8(+) T cells characterizes 
      tuberculosis-associated immune reconstitution inflammatory syndrome in patients 
      with HIV: a case control study.
PG  - 21
LID - 10.1186/1476-9255-10-21 [doi]
AB  - BACKGROUND: CD4(+) T cell activation indicators have been reported to be a common 
      phenomenon underlying diverse manifestations of immune reconstitution 
      inflammatory syndrome (IRIS). However, we have found that a high frequency of 
      circulating CD8(+) T cells is a specific risk factor for mycobacterial IRIS. 
      Therefore, we investigated whether CD8(+) T cells from patients who develop TB 
      IRIS were specifically activated. METHODS: We obtained PBMCs from HIV+ patients 
      prior to and 4, 8, 12, 24, 52 and 104 weeks after initiating antiretroviral 
      therapy. CD38 and HLADR expression on naive, central memory and effector memory 
      CD8(+) and CD4(+) T cells were determined by flow cytometry. Absolute counts and 
      frequencies of CD8(+) T cell subsets were compared between patients who developed 
      TB IRIS, who developed other IRIS forms and who remained IRIS-free. RESULTS: TB 
      IRIS patients showed significantly higher counts of naive CD8(+) T cells than the 
      other groups at most time points, with a contraction of the effector memory 
      subpopulation occurring later in the follow-up period. Activated (CD38(+) 
      HLADR(+)) CD8(+) T cells from all groups decreased with treatment but transiently 
      peaked in TB IRIS patients. This increase was due to an increase in activated 
      naive CD8(+) T cell counts during IRIS. Additionally, the CD8(+) T cell 
      subpopulations of TB IRIS patients expressed HLADR without CD38 more frequently 
      and expressed CD38 without HLADR less frequently than cells from other groups. 
      CONCLUSIONS: CD8(+) T cell activation is specifically relevant to TB IRIS. 
      Different IRIS forms may involve different alterations in T cell subsets, 
      suggesting different underlying inflammatory processes.
FAU - Espinosa, Enrique
AU  - Espinosa E
AD  - Center for Infectious Diseases Research (CIENI), Instituto Nacional de 
      Enfermedades Respiratorias "Ismael Cosio Villegas", Calzada de Tlalpan 4502, 
      14080 Mexico, D.F.Mexico.
AD  - Present address: Laboratorio de Inmunobiologia y Genetica, Instituto Nacional de 
      Enfermedades Respiratorias "Ismael Cosio Villegas", Calzada de Tlalpan 4502, 
      14080 Mexico, D.F.Mexico.
FAU - Romero-Rodriguez, Damaris P
AU  - Romero-Rodriguez DP
AD  - Center for Infectious Diseases Research (CIENI), Instituto Nacional de 
      Enfermedades Respiratorias "Ismael Cosio Villegas", Calzada de Tlalpan 4502, 
      14080 Mexico, D.F.Mexico.
AD  - Present address: Laboratorio de Inmunobiologia y Genetica, Instituto Nacional de 
      Enfermedades Respiratorias "Ismael Cosio Villegas", Calzada de Tlalpan 4502, 
      14080 Mexico, D.F.Mexico.
FAU - Cantoral-Diaz, Maria-Teresa
AU  - Cantoral-Diaz MT
AD  - Center for Infectious Diseases Research (CIENI), Instituto Nacional de 
      Enfermedades Respiratorias "Ismael Cosio Villegas", Calzada de Tlalpan 4502, 
      14080 Mexico, D.F.Mexico.
FAU - Reyes-Teran, Gustavo
AU  - Reyes-Teran G
AD  - Center for Infectious Diseases Research (CIENI), Instituto Nacional de 
      Enfermedades Respiratorias "Ismael Cosio Villegas", Calzada de Tlalpan 4502, 
      14080 Mexico, D.F.Mexico.
LA  - eng
PT  - Journal Article
DEP - 20130520
PL  - England
TA  - J Inflamm (Lond)
JT  - Journal of inflammation (London, England)
JID - 101232234
PMC - PMC3679878
OTO - NOTNLM
OT  - Activation
OT  - CD8 T cells
OT  - HIV-1
OT  - HIV-2
OT  - Highly active anti-retroviral therapy (HAART)
OT  - Human immunodeficiency virus (AIDS)
OT  - Inflammation
EDAT- 2013/05/22 06:00
MHDA- 2013/05/22 06:01
PMCR- 2013/05/20
CRDT- 2013/05/22 06:00
PHST- 2012/05/03 00:00 [received]
PHST- 2013/05/13 00:00 [accepted]
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2013/05/22 06:01 [medline]
PHST- 2013/05/20 00:00 [pmc-release]
AID - 1476-9255-10-21 [pii]
AID - 10.1186/1476-9255-10-21 [doi]
PST - epublish
SO  - J Inflamm (Lond). 2013 May 20;10:21. doi: 10.1186/1476-9255-10-21. eCollection 
      2013.