PMID- 23688860
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20220224
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 58
DP  - 2013 Aug
TI  - Cognitive-enhancing effects of Rhus verniciflua bark extract and its active 
      flavonoids with neuroprotective and anti-inflammatory activities.
PG  - 355-61
LID - S0278-6915(13)00303-7 [pii]
LID - 10.1016/j.fct.2013.05.007 [doi]
AB  - The neuroprotective potential of flavonoids within the brain comprises 
      anti-apoptosis of neuronal cells, anti-neuroinflammation and enhancement of 
      cognitive function. We reported that Rhus vernciflua inhibits glutamate-induced 
      neurotoxicity in primary cultured rat cortical cells. Here we narrowed it down to 
      get neuroprotective fractions from the plant yielding flavonoid-rich ethyl 
      acetate fraction (PREF). Among its active flavonoids, fisetin exhibited not only 
      inhibitory effect against lipopolysaccharide (LPS)-induced neuroinflammation by 
      suppressing inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 but 
      also memory enhancing effects via reactivation of cAMP responsive element binding 
      protein (CREB)-brain derived neurotrophic factor (BDNF) pathway in 
      memory-impaired mice by scopolamine. Butein also showed a similar activity to 
      fisetin even though to a lesser extent. The neuroprotection by PREF and selected 
      flavonoids may involve maintenance of antioxidant defense mechanism including 
      glutathione peroxidase (GSH-Px), glutathione reductase (GR) and superoxide 
      dismutase (SOD). Conclusively, we demonstrate the R. vernciflua bark extract and 
      its active flavonoids with potent neuroprotective and anti-inflammatory effects 
      might be good therapeutic candidates as cognitive-enhancers.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Cho, Namki
AU  - Cho N
AD  - College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul 
      National University, Seoul 151-742, Republic of Korea.
FAU - Lee, Ki Yong
AU  - Lee KY
FAU - Huh, Jungmoo
AU  - Huh J
FAU - Choi, Ji Hoon
AU  - Choi JH
FAU - Yang, Heejung
AU  - Yang H
FAU - Jeong, Eun Ju
AU  - Jeong EJ
FAU - Kim, Hong Pyo
AU  - Kim HP
FAU - Sung, Sang Hyun
AU  - Sung SH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130518
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Flavonoids)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Plant Extracts)
RN  - DL48G20X8X (Scopolamine)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Antioxidants/pharmacology
MH  - Chromatography, High Pressure Liquid
MH  - Cognition/*drug effects
MH  - Flavonoids/*pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Nerve Tissue Proteins/metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - Oxidative Stress/drug effects
MH  - Plant Bark/chemistry
MH  - Plant Extracts/*pharmacology
MH  - Rhus/*chemistry
MH  - Scopolamine/pharmacology
OTO - NOTNLM
OT  - Anti-neuroinflammation
OT  - CREB-BDNF signaling
OT  - Cognitive-enhancing activity
OT  - Flavonoids
OT  - Rhus verniciflua bark
EDAT- 2013/05/22 06:00
MHDA- 2014/03/07 06:00
CRDT- 2013/05/22 06:00
PHST- 2013/03/08 00:00 [received]
PHST- 2013/04/26 00:00 [revised]
PHST- 2013/05/02 00:00 [accepted]
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - S0278-6915(13)00303-7 [pii]
AID - 10.1016/j.fct.2013.05.007 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2013 Aug;58:355-61. doi: 10.1016/j.fct.2013.05.007. Epub 2013 
      May 18.