PMID- 23688926
OWN - NLM
STAT- MEDLINE
DCOM- 20140806
LR  - 20131209
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Linking)
VI  - 76 Pt C
DP  - 2014 Jan
TI  - The function of BDNF in the adult auditory system.
PG  - 719-28
LID - S0028-3908(13)00218-9 [pii]
LID - 10.1016/j.neuropharm.2013.05.008 [doi]
AB  - The inner ear of vertebrates is specialized to perceive sound, gravity and 
      movements. Each of the specialized sensory organs within the cochlea (sound) and 
      vestibular system (gravity, head movements) transmits information to specific 
      areas of the brain. During development, brain-derived neurotrophic factor (BDNF) 
      orchestrates the survival and outgrowth of afferent fibers connecting the 
      vestibular organ and those regions in the cochlea that map information for low 
      frequency sound to central auditory nuclei and higher-auditory centers. The role 
      of BDNF in the mature inner ear is less understood. This is mainly due to the 
      fact that constitutive BDNF mutant mice are postnatally lethal. Only in the last 
      few years has the improved technology of performing conditional cell specific 
      deletion of BDNF in vivo allowed the study of the function of BDNF in the mature 
      developed organ. This review provides an overview of the current knowledge of the 
      expression pattern and function of BDNF in the peripheral and central auditory 
      system from just prior to the first auditory experience onwards. A special focus 
      will be put on the differential mechanisms in which BDNF drives refinement of 
      auditory circuitries during the onset of sensory experience and in the adult 
      brain. This article is part of the Special Issue entitled 'BDNF Regulation of 
      Synaptic Structure, Function, and Plasticity'.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Singer, Wibke
AU  - Singer W
AD  - University of Tubingen, Department of Otolaryngology, Head and Neck Surgery, 
      Tubingen Hearing Research Centre (THRC), Molecular Physiology of Hearing, 
      Elfriede-Aulhorn-Strasse 5, 72076 Tubingen, Germany.
FAU - Panford-Walsh, Rama
AU  - Panford-Walsh R
FAU - Knipper, Marlies
AU  - Knipper M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130518
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Auditory Pathways/anatomy & histology/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Humans
MH  - Mice
MH  - Neuronal Plasticity/physiology
MH  - Wounds and Injuries/metabolism/pathology
OTO - NOTNLM
OT  - ABR
OT  - AC
OT  - ACTH
OT  - AF
OT  - AN
OT  - Acoustic trauma
OT  - Arc
OT  - Auditory system
OT  - BDNF
OT  - BLA
OT  - CN
OT  - CRH
OT  - Cochlea
OT  - Corticotropin-releasing hormone
OT  - DCN
OT  - EE
OT  - EF
OT  - HPA axis
OT  - IC
OT  - IHC
OT  - Inhibition
OT  - K(v) current
OT  - LSO
OT  - MGB
OT  - MSO
OT  - OHC
OT  - POMC
OT  - Plasticity
OT  - SC
OT  - SG
OT  - SOC
OT  - SR
OT  - TM
OT  - VCN
OT  - VHC
OT  - activity-regulated gene
OT  - adrenocorticotropin hormone
OT  - afferent fibre
OT  - auditory brainstem response
OT  - auditory cortex
OT  - auditory nerve
OT  - basolateral amygdala
OT  - cochlear nucleus
OT  - dorsal cochlear nucleus
OT  - efferent fibre
OT  - environmental enrichment
OT  - hypothalamic-pituitary-adrenal axis
OT  - inferior colliculus
OT  - inner hair cell
OT  - lateral superior olive
OT  - medial geniculate body
OT  - medial superior olive
OT  - outer hair cell
OT  - pro-opiomelanocortin
OT  - spiral ganglion
OT  - spontaneous rate
OT  - superior olivary complex
OT  - supporting cell
OT  - tectorial membrane
OT  - ventral cochlear nucleus
OT  - vestibular hair cell
OT  - voltage dependent potassium current
EDAT- 2013/05/22 06:00
MHDA- 2014/08/07 06:00
CRDT- 2013/05/22 06:00
PHST- 2013/03/13 00:00 [received]
PHST- 2013/05/03 00:00 [revised]
PHST- 2013/05/06 00:00 [accepted]
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2014/08/07 06:00 [medline]
AID - S0028-3908(13)00218-9 [pii]
AID - 10.1016/j.neuropharm.2013.05.008 [doi]
PST - ppublish
SO  - Neuropharmacology. 2014 Jan;76 Pt C:719-28. doi: 
      10.1016/j.neuropharm.2013.05.008. Epub 2013 May 18.