PMID- 23688984
OWN - NLM
STAT- MEDLINE
DCOM- 20140724
LR  - 20161125
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 33
IP  - 5
DP  - 2013 May
TI  - [Changes in gene expression profiles in multiple myeloma cells after 
      knocking-down SNF5, a core subunit of SWI/SNF complex].
PG  - 667-71
AB  - OBJECTIVE: To investigate the changes in the gene expression profiles in a 
      multiple myeloma cell line after knocking-down the expression of SNF5, a core 
      component of the SWI/SNF chromatin remodeling complex. METHODS: The total RNA 
      were extracted from tetracycline-inducible SNF5 knockdown (KD) cell line derived 
      from KM3 cells for gene expression profiling by affymetrix microarray and 
      bioinformatic analysis. RESULTS: Knockdown of SNF5 inhibited KM3 cell 
      proliferation. A total of 545 genes were found to be differentially expressed in 
      the cells with SNF5 knockdown, among which 214 were up-regulated and 331 were 
      down-regulated. CONCLUSIONS: SNF5 is essential for the growth of multiple myeloma 
      cells and can regulate the expression of the genes associated with cell growth 
      and apoptosis.
FAU - Xie, Yingying
AU  - Xie Y
AD  - Department of Hematology, Zhejiang University, Hangzhou, China. 
      xstyingying@163.com
FAU - Xu, Yang
AU  - Xu Y
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (SMARCB1 Protein)
RN  - 0 (SMARCB1 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Apoptosis
MH  - Cell Line, Tumor
MH  - Cell Proliferation
MH  - Chromosomal Proteins, Non-Histone/*genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Multiple Myeloma/*genetics/pathology
MH  - RNA, Small Interfering
MH  - SMARCB1 Protein
MH  - Transcription Factors/*genetics
MH  - *Transcriptome
EDAT- 2013/05/22 06:00
MHDA- 2014/07/25 06:00
CRDT- 2013/05/22 06:00
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2014/07/25 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2013 May;33(5):667-71.