PMID- 23689097
OWN - NLM
STAT- MEDLINE
DCOM- 20140204
LR  - 20211122
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 92
IP  - 7
DP  - 2013 Aug
TI  - Neonatal-maternal factors and perfluoroalkyl substances in cord blood.
PG  - 843-50
LID - S0045-6535(13)00636-X [pii]
LID - 10.1016/j.chemosphere.2013.04.038 [doi]
AB  - Perfluoroalkyl substances (PFASs) can cross the placenta, enter fetal 
      circulation, and were found to correlate with adverse fetal growth. However, 
      determinants of cord blood PFASs are not fully characterized. The study aimed to 
      explore the association between PFASs and neonatal-maternal factors within a 
      Taiwanese birth cohort. We selected subjects from Taiwan Birth Panel Study, which 
      enrolled 486 infant-mother pairs in 2004-2005. We collected cord blood and 
      analyzed perfluorooctanoic acid (PFOA), perfluorooctanyl sulfonate (PFOS), 
      perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUA) using a simple 
      protein precipitation and an ultra-high performance liquid chromatography/tandem 
      mass spectrometry. We retrieved information pertaining to maternal 
      socio-demographics, lifestyle- and dietary-related factors through structured 
      questionnaires during the postpartum hospital stay. A total of 439 subjects, with 
      90% response rate, have completed serum analysis and questionnaire survey. The 
      median concentrations for PFOA, PFOS, PFNA, and PFUA in cord blood were 1.86, 
      5.67, 3.00, and 13.5ngmL(-1), respectively. After adjusting for potential 
      confounders, multiple linear regression models revealed that log10-PFOA was 
      positively associated with maternal age (beta=0.011) and negatively associated with 
      multiparity (beta=-0.044). Log10-PFOS was negatively correlated with birth weight 
      (beta=-0.011) and higher maternal education (senior high school: beta=-0.067; 
      university: beta=-0.088). Log10-PFUA tended to negatively associate with gender, 
      male infants (beta=-0.075), and using cosmetics during pregnancy (beta=-0.065). 
      Interestingly, presence of cockroaches in the home was positively associated with 
      log10-PFOA (beta=0.041) and 1og10-PFNA (beta=0.123). In conclusion, this study 
      demonstrated several factors to correlate with cord blood PFASs and further 
      investigation are still needed for confirmation of exposure routes.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Lien, Guang-Wen
AU  - Lien GW
AD  - Institute of Occupational Medicine and Industrial Hygiene, National Taiwan 
      University College of Public Health, Taipei, Taiwan.
FAU - Huang, Ching-Chun
AU  - Huang CC
FAU - Wu, Kuen-Yuh
AU  - Wu KY
FAU - Chen, Mei-Huei
AU  - Chen MH
FAU - Lin, Chien-Yu
AU  - Lin CY
FAU - Chen, Chia-Yang
AU  - Chen CY
FAU - Hsieh, Wu-Shiun
AU  - Hsieh WS
FAU - Chen, Pau-Chung
AU  - Chen PC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130518
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Cosmetics)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fatty Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (perfluoroundecanoic acid)
RN  - 375-95-1 (perfluoro-n-nonanoic acid)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Adult
MH  - Alkanesulfonic Acids/blood
MH  - Animals
MH  - Birth Weight
MH  - Caprylates/blood
MH  - Chromatography, High Pressure Liquid/methods
MH  - Cockroaches
MH  - Cosmetics/adverse effects
MH  - Environmental Pollutants/*blood
MH  - Fatty Acids/blood
MH  - Female
MH  - Fetal Blood/*chemistry
MH  - Fluorocarbons/*blood
MH  - Humans
MH  - Infant, Newborn
MH  - Life Style
MH  - Male
MH  - Maternal Exposure
MH  - Pregnancy
MH  - Regression Analysis
MH  - Social Class
MH  - Surveys and Questionnaires
MH  - Taiwan
MH  - Tandem Mass Spectrometry
EDAT- 2013/05/22 06:00
MHDA- 2014/02/05 06:00
CRDT- 2013/05/22 06:00
PHST- 2012/10/19 00:00 [received]
PHST- 2013/03/15 00:00 [revised]
PHST- 2013/04/08 00:00 [accepted]
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2014/02/05 06:00 [medline]
AID - S0045-6535(13)00636-X [pii]
AID - 10.1016/j.chemosphere.2013.04.038 [doi]
PST - ppublish
SO  - Chemosphere. 2013 Aug;92(7):843-50. doi: 10.1016/j.chemosphere.2013.04.038. Epub 
      2013 May 18.