PMID- 23689115
OWN - NLM
STAT- MEDLINE
DCOM- 20140227
LR  - 20220317
IS  - 1423-0267 (Electronic)
IS  - 0030-3755 (Linking)
VI  - 230
IP  - 1
DP  - 2013
TI  - Structural and functional assessment of macula in patients with high-risk 
      proliferative diabetic retinopathy submitted to panretinal photocoagulation and 
      associated intravitreal bevacizumab injections: a comparative, randomised, 
      controlled trial.
PG  - 1-8
LID - 10.1159/000348605 [doi]
AB  - PURPOSE: To compare the efficacy of therapy with panretinal photocoagulation 
      (PRP) and intravitreal bevacizumab (IVB) injections versus PRP alone in patients 
      with high-risk proliferative diabetic retinopathy (HR-PDR) with a 6-month 
      follow-up. METHODS: Forty-two patients with HR-PDR were prospectively studied in 
      a randomised, masked, controlled trial. Both eyes of each patient were randomised 
      either to the study group (SG) receiving PRP plus IVB injections or the control 
      group (CG) receiving PRP alone. Mean change in visual acuity (VA), optical 
      coherence tomography-measured foveal thickness (FT) and macular volume (MV) were 
      compared. RESULTS: Intergroup comparisons showed no significant difference in VA 
      while FT exhibited a significant (p < 0.05) difference at 1 month of follow-up 
      and MV was significantly reduced at the 1- and 3-month follow-up. Compared to 
      baseline, VA was significantly worse at all follow-ups in the CG and was stable 
      in the SG. FT increased significantly in the CG from baseline to the 1- and 
      6-month follow-ups and in the SG, no significant difference was observed. MV was 
      significantly increased in the CG during all follow-up periods. CONCLUSION: In 
      HR-PDR, using IVB injections as adjuvant treatment to PRP reduces the VA 
      deterioration and results in decreased FT and MV measurements compared to PRP 
      alone.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Preti, Rony Carlos
AU  - Preti RC
AD  - Division of Ophthalmology, University of Sao Paulo Medical School, Sao Paulo, 
      Brazil.
FAU - Vasquez Ramirez, Lisa Mariel
AU  - Vasquez Ramirez LM
FAU - Ribeiro Monteiro, Mario Luiz
AU  - Ribeiro Monteiro ML
FAU - Pelayes, David E
AU  - Pelayes DE
FAU - Takahashi, Walter Yukihiko
AU  - Takahashi WY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20130514
PL  - Switzerland
TA  - Ophthalmologica
JT  - Ophthalmologica. Journal international d'ophtalmologie. International journal of 
      ophthalmology. Zeitschrift fur Augenheilkunde
JID - 0054655
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 2S9ZZM9Q9V (Bevacizumab)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiogenesis Inhibitors/*administration & dosage
MH  - Antibodies, Monoclonal, Humanized/*administration & dosage
MH  - Bevacizumab
MH  - Combined Modality Therapy
MH  - Diabetic Retinopathy/*drug therapy/pathology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Intravitreal Injections
MH  - Light Coagulation/*methods
MH  - Macula Lutea/*drug effects/pathology
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Tomography, Optical Coherence
MH  - Treatment Outcome
MH  - Visual Acuity
EDAT- 2013/05/22 06:00
MHDA- 2014/02/28 06:00
CRDT- 2013/05/22 06:00
PHST- 2012/09/14 00:00 [received]
PHST- 2013/02/02 00:00 [accepted]
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2014/02/28 06:00 [medline]
AID - 000348605 [pii]
AID - 10.1159/000348605 [doi]
PST - ppublish
SO  - Ophthalmologica. 2013;230(1):1-8. doi: 10.1159/000348605. Epub 2013 May 14.