PMID- 23689439
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20151119
IS  - 1423-0291 (Electronic)
IS  - 1015-2008 (Linking)
VI  - 80
IP  - 5
DP  - 2013
TI  - Expression of insulin-like growth factor 1 and insulin-like growth factor 1 
      receptor is associated with the favorable clinicopathologic parameters in small 
      intestinal carcinomas.
PG  - 265-70
LID - 10.1159/000350309 [doi]
AB  - OBJECTIVE: The insulin-like growth factor (IGF) system has been known to play a 
      critical role in tumor development and progression in many human cancers. 
      However, the role of the IGF system in small intestinal carcinoma (SIC) has not 
      been studied yet. METHODS: We evaluated the expression of IGF1 and IGF1 receptor 
      (IFG1R) in a total of 194 cases of SIC. RESULTS: IGF1 expression was associated 
      with well/moderate differentiation, better survival, lower pT, lower stage and no 
      lymph node metastasis. IGF1R was more diffusely and strongly expressed in tumors 
      with lower pT and lower stage. CONCLUSIONS: IGF1 and IGF1R expression is 
      associated with favorable clinicopathologic parameters and may involve early 
      carcinogenesis of SICs. Target therapy for the IGF1R signaling pathway may not 
      have a major therapeutic role in treating SIC.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Shin, Hyung Chan
AU  - Shin HC
AD  - Department of Pathology, Yeungnam University College of Medicine, Daegu 705-717, 
      Korea.
FAU - Bae, Young Kyung
AU  - Bae YK
FAU - Gu, Mi Jin
AU  - Gu MJ
FAU - Jung, Eun Sun
AU  - Jung ES
FAU - Oh, Young-Ha
AU  - Oh YH
CN  - Korean Small Intestinal Cancer Study Group
LA  - eng
PT  - Journal Article
DEP - 20130516
PL  - Switzerland
TA  - Pathobiology
JT  - Pathobiology : journal of immunopathology, molecular and cellular biology
JID - 9007504
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (IGF1 protein, human)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.10.1 (Receptor, IGF Type 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma/*chemistry/mortality/pathology
MH  - Cell Differentiation
MH  - Chi-Square Distribution
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Intestinal Neoplasms/*chemistry/mortality/pathology
MH  - Intestine, Small/*chemistry/pathology
MH  - Kaplan-Meier Estimate
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Receptor, IGF Type 1/*analysis
MH  - Tissue Array Analysis
MH  - Young Adult
EDAT- 2013/05/22 06:00
MHDA- 2014/01/15 06:00
CRDT- 2013/05/22 06:00
PHST- 2013/01/15 00:00 [received]
PHST- 2013/02/27 00:00 [accepted]
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - 000350309 [pii]
AID - 10.1159/000350309 [doi]
PST - ppublish
SO  - Pathobiology. 2013;80(5):265-70. doi: 10.1159/000350309. Epub 2013 May 16.