PMID- 23689518
OWN - NLM
STAT- MEDLINE
DCOM- 20131018
LR  - 20191210
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 161
IP  - 4
DP  - 2013
TI  - Tolerogenic dendritic cells: key regulators of peripheral tolerance in health and 
      disease.
PG  - 293-303
LID - 10.1159/000350328 [doi]
AB  - Dendritic cells (DCs) as professional antigen-presenting cells are able to induce 
      immunity and tolerance in different conditions, which leads to strong immune 
      responses against hostile agents or tolerance to self-antigens. Although for 
      subsets of DCs, a regulatory function has been shown, the role of the 
      microenvironment is momentous to generate tolerogenic DCs (tDCs). Different 
      microorganisms and tumor cells escape from immune responses by producing 
      mediators and components that influence DCs to show tolerogenic characteristics. 
      In this review, tDC induction was explained in steady state and disease 
      conditions. Moreover, an overview was presented on the efforts to generate in 
      vitro tDCs, their clinical applications and the problems which remain to be 
      solved in this field.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Saei, Azad
AU  - Saei A
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Hadjati, Jamshid
AU  - Hadjati J
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130514
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Autoantigens)
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Autoantigens/immunology
MH  - Cellular Microenvironment
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Evasion
MH  - Immunomodulation
MH  - Immunotherapy/*methods/trends
MH  - Infections/*immunology
MH  - Neoplasms/*immunology
MH  - *Peripheral Tolerance
EDAT- 2013/05/22 06:00
MHDA- 2013/10/19 06:00
CRDT- 2013/05/22 06:00
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2013/10/19 06:00 [medline]
AID - 000350328 [pii]
AID - 10.1159/000350328 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2013;161(4):293-303. doi: 10.1159/000350328. Epub 2013 
      May 14.