PMID- 23690656
OWN - NLM
STAT- MEDLINE
DCOM- 20131203
LR  - 20211021
IS  - 1466-1861 (Electronic)
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 2013
DP  - 2013
TI  - Serum matrix metalloproteinase-3 in comparison with acute phase proteins as a 
      marker of disease activity and radiographic damage in early rheumatoid arthritis.
PG  - 183653
LID - 10.1155/2013/183653 [doi]
LID - 183653
AB  - Matrix metalloproteinase-3 (MMP-3) is involved in the immunopathogenesis of 
      rheumatoid arthritis (RA), but little is known about its relationship to genetic 
      susceptibility and biomarkers of disease activity, especially acute phase 
      reactants in early RA. MMP-3 was measured by ELISA in serum samples of 128 
      disease-modifying, drug-naive patients and analysed in relation to shared epitope 
      genotype, a range of circulating chemokines/cytokines, acute phase reactants, 
      autoantibodies, cartilage oligomeric protein (COMP), and the simplified disease 
      activity index (SDAI). MMP-3 was elevated >1.86 ng/ml in 56.25% of patients (P < 
      0.0001), correlated with several biomarkers, notably IL-8, IL-6, IFN gamma , VEGF and 
      COMP (r values = 0.22-0.33, P < 0.014-0.0001) and with CRP and SAA levels (r = 
      0.40 and 0.41, resp., P < 0.0000) and SDAI (r = 0.29, P < 0.0001), but not with 
      erosions or nodulosis. However, the correlations of CRP and SAA with SDAI were 
      stronger (respective values of 0.63 and 0.54, P < 0.001 for both). COMP 
      correlated with smoking, RF, and MMP-3. MMP-3 is significantly associated with 
      disease activity, inflammatory mediators and cartilage breakdown, making it a 
      potential biomarker of disease severity, but seemingly less useful than CRP and 
      SAA as a biomarker of disease activity in early RA.
FAU - Ally, Mahmood M T M
AU  - Ally MM
AD  - Department of Internal Medicine, Faculty of Health Sciences, University of 
      Pretoria, Pretoria 0001, South Africa. tar@up.ac.za
FAU - Hodkinson, Bridget
AU  - Hodkinson B
FAU - Meyer, Pieter W A
AU  - Meyer PW
FAU - Musenge, Eustasius
AU  - Musenge E
FAU - Tikly, Mohammed
AU  - Tikly M
FAU - Anderson, Ronald
AU  - Anderson R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130407
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Matrilin Proteins)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Acute-Phase Proteins/*metabolism
MH  - Arthritis, Rheumatoid/*blood/*diagnostic imaging/pathology
MH  - Autoantibodies/blood
MH  - Biomarkers/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Matrilin Proteins/blood
MH  - Matrix Metalloproteinase 3/*blood
MH  - Radiography
MH  - Smoking/blood
PMC - PMC3649689
EDAT- 2013/05/22 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/04/07
CRDT- 2013/05/22 06:00
PHST- 2012/12/10 00:00 [received]
PHST- 2013/02/26 00:00 [accepted]
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/04/07 00:00 [pmc-release]
AID - 10.1155/2013/183653 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2013;2013:183653. doi: 10.1155/2013/183653. Epub 2013 Apr 7.