PMID- 23691270
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 2081-3856 (Print)
IS  - 2081-6936 (Electronic)
IS  - 2081-6936 (Linking)
VI  - 4
IP  - 1
DP  - 2013 Mar 1
TI  - The Role of Neurotrophins in Major Depressive Disorder.
PG  - 46-58
AB  - Neurotrophins and other growth factors have been advanced as critical modulators 
      of depressive behavior. Support for this model is based on analyses of knockout 
      and transgenic mouse models, human genetic studies, and screens for gene products 
      that are regulated by depressive behavior and/or antidepressants. Even subtle 
      alteration in the regulated secretion of brain-derived neurotrophic factor 
      (BDNF), for example, due to a single nucleotide polymorphism (SNP)-encoded 
      Val-Met substitution in proBDNF that affects processing and sorting, impacts 
      behavior and cognition. Alterations in growth factor expression result in changes 
      in neurogenesis as well as structural changes in neuronal cytoarchitecture, 
      including effects on dendritic length and spine density, in the hippocampus, 
      nucleus accumbens, and prefrontal cortex. These changes have the potential to 
      impact the plasticity and stability of synapses in the CNS, and the complex brain 
      circuitry that regulates behavior. Here we review the role that neurotrophins 
      play in the modulation of depressive behavior, and the downstream signaling 
      targets they regulate that potentially mediate these behavioral pro-depressant 
      and antidepressant effects.
FAU - Jiang, Cheng
AU  - Jiang C
AD  - Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New 
      York, NY 10029 USA ; Graduate School of Biomedical Sciences, Icahn School of 
      Medicine at Mount Sinai, New York, NY 10029 USA.
FAU - Salton, Stephen R
AU  - Salton SR
LA  - eng
GR  - R01 MH086499/MH/NIMH NIH HHS/United States
GR  - R21 MH083496/MH/NIMH NIH HHS/United States
GR  - R33 MH083496/MH/NIMH NIH HHS/United States
PT  - Journal Article
PL  - Germany
TA  - Transl Neurosci
JT  - Translational neuroscience
JID - 101550327
PMC - PMC3656715
MID - NIHMS455681
OTO - NOTNLM
OT  - Antidepressant
OT  - Arc
OT  - Brain-Derived Neurotrophic Factor (BDNF)
OT  - Depression
OT  - Ketamine
OT  - Nerve Growth Factor (NGF)
OT  - Neuritin
OT  - Neurtrophin-3 (NT-3)
OT  - Trk
OT  - VGF
EDAT- 2013/05/22 06:00
MHDA- 2013/05/22 06:01
PMCR- 2014/03/01
CRDT- 2013/05/22 06:00
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2013/05/22 06:01 [medline]
PHST- 2014/03/01 00:00 [pmc-release]
AID - 10.2478/s13380-013-0103-8 [doi]
PST - ppublish
SO  - Transl Neurosci. 2013 Mar 1;4(1):46-58. doi: 10.2478/s13380-013-0103-8.