PMID- 23691278
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130522
LR  - 20220330
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2013
DP  - 2013
TI  - Photoreceptor impairment and restoration on optical coherence tomographic image.
PG  - 518170
LID - 10.1155/2013/518170 [doi]
LID - 518170
AB  - With recent development of spectral-domain optical coherence tomography (SD-OCT), 
      the pathological changes of retina can be observed in much greater detail. SD-OCT 
      clearly delineates three highly reflective lines in the outer retina, which are 
      external limiting membrane (ELM), photoreceptor inner and outer segment (IS/OS) 
      junction, and cone outer segment tips (COST) in order from inside. These lines 
      can serve as hallmarks for the evaluation of photoreceptor condition. In 
      retinitis pigmentosa (RP) leading to photoreceptor degeneration, the ELM, IS/OS, 
      and COST lines are shortened with the progression of the disease. In addition, 
      shortening of the ELM, IS/OS and COST lines is significantly associated with each 
      other. The line length is longest in the ELM, followed by the IS/OS, and COST, 
      suggesting that retinal layer becomes disorganized first at the COST, followed by 
      the IS/OS and finally the ELM. This finding is consistent with the previous 
      report that the earliest histopathological change in RP is a shortening of the 
      photoreceptor outer segments. On the other hand, retinal layer becomes restored 
      first at the ELM, followed by the IS/OS and finally the COST after macular hole 
      surgery. There may be a directionality of photoreceptor impairment or restoration 
      on optical coherence tomographic image.
FAU - Mitamura, Yoshinori
AU  - Mitamura Y
AD  - Department of Ophthalmology, Institute of Health Biosciences, The University of 
      Tokushima Graduate School, Tokushima 770-8503, Japan.
FAU - Mitamura-Aizawa, Sayaka
AU  - Mitamura-Aizawa S
FAU - Katome, Takashi
AU  - Katome T
FAU - Naito, Takeshi
AU  - Naito T
FAU - Hagiwara, Akira
AU  - Hagiwara A
FAU - Kumagai, Ken
AU  - Kumagai K
FAU - Yamamoto, Shuichi
AU  - Yamamoto S
LA  - eng
PT  - Journal Article
DEP - 20130403
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC3649344
EDAT- 2013/05/22 06:00
MHDA- 2013/05/22 06:01
PMCR- 2013/04/03
CRDT- 2013/05/22 06:00
PHST- 2013/01/08 00:00 [received]
PHST- 2013/03/17 00:00 [accepted]
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2013/05/22 06:01 [medline]
PHST- 2013/04/03 00:00 [pmc-release]
AID - 10.1155/2013/518170 [doi]
PST - ppublish
SO  - J Ophthalmol. 2013;2013:518170. doi: 10.1155/2013/518170. Epub 2013 Apr 3.