PMID- 23691331
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130522
LR  - 20231106
IS  - 2090-3448 (Print)
IS  - 2090-3456 (Electronic)
VI  - 2013
DP  - 2013
TI  - Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed 
      through the Scope of the Immunopathological Classification.
PG  - 268625
LID - 10.1155/2013/268625 [doi]
LID - 268625
AB  - Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are benign 
      hepatocellular tumors. The risk of bleeding and malignant transformation of HCA 
      are strong arguments to differentiate HCA from FNH. Despite great progress that 
      has been made in the differential radiological diagnosis of the 2 types of 
      nodules, liver biopsy is sometimes necessary to separate the 2 entities. 
      Identification of HCA subtypes using immunohistochemical techniques, namely, 
      HNF1A-inactivated HCA (35-40%), inflammatory HCA (IHCA), and beta-catenin-mutated 
      inflammatory HCA (b-IHCA) (50-55%), beta-catenin-activated HCA (5-10%), and 
      unclassified HCA (10%) has greatly improved the diagnostic accuracy of benign 
      hepatocellular nodules. If HCA malignant transformation occurs in all HCA 
      subgroups, the risk is by far the highest in the beta -catenin-mutated subgroups 
      (b-HCA, b-IHCA). In the coming decade the management of HCA will be more 
      dependent on the identification of HCA subtypes, particularly for smaller nodules 
      (<5 cm) in terms of imaging, follow-up, and resection.
FAU - Balabaud, Charles
AU  - Balabaud C
AD  - Inserm U1053, Universite Bordeaux Segalen, 33076 Bordeaux Cedex, France.
FAU - Al-Rabih, Wesal R
AU  - Al-Rabih WR
FAU - Chen, Pei-Jer
AU  - Chen PJ
FAU - Evason, Kimberley
AU  - Evason K
FAU - Ferrell, Linda
AU  - Ferrell L
FAU - Hernandez-Prera, Juan C
AU  - Hernandez-Prera JC
FAU - Huang, Shiu-Feng
AU  - Huang SF
FAU - Longerich, Thomas
AU  - Longerich T
FAU - Park, Young Nyun
AU  - Park YN
FAU - Quaglia, Alberto
AU  - Quaglia A
FAU - Schirmacher, Peter
AU  - Schirmacher P
FAU - Sempoux, Christine
AU  - Sempoux C
FAU - Thung, Swan N
AU  - Thung SN
FAU - Torbenson, Michael
AU  - Torbenson M
FAU - Wee, Aileen
AU  - Wee A
FAU - Yeh, Matthew M
AU  - Yeh MM
FAU - Yeh, Shiou-Hwei
AU  - Yeh SH
FAU - Le Bail, Brigitte
AU  - Le Bail B
FAU - Zucman-Rossi, Jessica
AU  - Zucman-Rossi J
FAU - Bioulac-Sage, Paulette
AU  - Bioulac-Sage P
LA  - eng
PT  - Journal Article
DEP - 20130414
PL  - United States
TA  - Int J Hepatol
JT  - International journal of hepatology
JID - 101564967
PMC - PMC3654480
EDAT- 2013/05/22 06:00
MHDA- 2013/05/22 06:01
PMCR- 2013/04/14
CRDT- 2013/05/22 06:00
PHST- 2012/11/05 00:00 [received]
PHST- 2012/12/25 00:00 [accepted]
PHST- 2013/05/22 06:00 [entrez]
PHST- 2013/05/22 06:00 [pubmed]
PHST- 2013/05/22 06:01 [medline]
PHST- 2013/04/14 00:00 [pmc-release]
AID - 10.1155/2013/268625 [doi]
PST - ppublish
SO  - Int J Hepatol. 2013;2013:268625. doi: 10.1155/2013/268625. Epub 2013 Apr 14.