PMID- 23694703
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20181202
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 250
DP  - 2013 Oct 10
TI  - Involvement of pGluR1, EAAT2 and EAAT3 in offspring depression induced by 
      prenatal stress.
PG  - 333-41
LID - S0306-4522(13)00356-4 [pii]
LID - 10.1016/j.neuroscience.2013.04.031 [doi]
AB  - It is widely known that prenatal stress (PS) exposure causes depression-like 
      behaviour to offspring, as well as maladaptive responses including 
      neurobiological and physiological changes. However, the underlying mechanism of 
      PS induced juvenile-onset depression remains largely unravelled. The inadequacies 
      of monoamine deficiency hypothesis, the emerging evidence of altered glutamate 
      neurotransmission in mood disorders, as well as our previous studies inspired us 
      to assess the potential role of glutamatergic system in the pathogenesis of 
      juvenile depression. In this research, we examined the expression of 
      phosphorylated GluR1 subunit of ionotropic receptor 
      alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR), the 
      Na+-dependent glutamate transporters excitatory amino acid transporter 2 (EAAT2) 
      and EAAT3 in the hippocampus, striatum and frontal cortex of 1-month-old rat 
      offspring after mid and late PS exposure. Prenatally stressed offspring rats 
      showed significantly prolonged duration of immobility and shortened immobility 
      latency in tail suspension test. We also detected that PS significantly altered 
      the expression of glutamate receptor and glutamate transporters of these 
      depressed rats. In brief, the changes of phosphorylated GluR1 subunit of AMPAR 
      protein level in the hippocampus and frontal cortex, as well as markedly 
      decreased EAAT2 mRNA expression in the hippocampus, striatum and frontal cortex 
      and EAAT3 mRNA expression in the hippocampus of stressed rats were both observed. 
      These results underpinned that glutamate receptors and glutamate transporters 
      might be involved in the progress of depression-like behaviour in juvenile rat 
      offspring induced by PS.
CI  - Copyright (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Zhang, X H
AU  - Zhang XH
AD  - Department of Pharmacology, College of Medicine, Xi'an Jiaotong University, 
      86-710061 Shaanxi, China.
FAU - Jia, N
AU  - Jia N
FAU - Zhao, X Y
AU  - Zhao XY
FAU - Tang, G K
AU  - Tang GK
FAU - Guan, L X
AU  - Guan LX
FAU - Wang, D
AU  - Wang D
FAU - Sun, H L
AU  - Sun HL
FAU - Li, H
AU  - Li H
FAU - Zhu, Z L
AU  - Zhu ZL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130518
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Excitatory Amino Acid Transporter 2)
RN  - 0 (Excitatory Amino Acid Transporter 3)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Slc1a1 protein, rat)
RN  - 0 (Slc1a2 protein, rat)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 63231-63-0 (RNA)
RN  - TFZ3H25BS1 (glutamate receptor ionotropic, AMPA 1)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Depression/etiology/*psychology
MH  - Excitatory Amino Acid Transporter 2/*physiology
MH  - Excitatory Amino Acid Transporter 3/*physiology
MH  - Female
MH  - Glutamic Acid/physiology
MH  - Hindlimb Suspension
MH  - Hippocampus/metabolism
MH  - Neostriatum/metabolism
MH  - Prefrontal Cortex/metabolism
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*psychology
MH  - RNA/biosynthesis/isolation & purification
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, AMPA/*physiology
MH  - Restraint, Physical
OTO - NOTNLM
OT  - AMPAR
OT  - BPD
OT  - CON
OT  - EAAT
OT  - EAAT2
OT  - EAAT3
OT  - EDTA
OT  - EGTA
OT  - GAPDH
OT  - LPS
OT  - MD
OT  - MPS
OT  - PBST
OT  - PS
OT  - SDS-PAGE
OT  - TST
OT  - alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
OT  - bipolar disorder
OT  - control group
OT  - depression
OT  - ethylene glycol tetraacetic acid
OT  - ethylenediaminetetraacetic acid
OT  - excitatory amino acid transporter
OT  - glyceraldehyde 3-phosphate dehydrogenase
OT  - late prenatal stress group
OT  - major depression
OT  - mid prenatal stress group
OT  - pGluR1
OT  - phosphate-buffered saline with 0.1% Tween-20
OT  - phosphorylated GluR1 subunit of AMPAR
OT  - prenatal stress
OT  - sodium dodecyl sulfate polyacrylamide gel electrophoresis
OT  - tail suspension test
EDAT- 2013/05/23 06:00
MHDA- 2014/04/05 06:00
CRDT- 2013/05/23 06:00
PHST- 2012/12/07 00:00 [received]
PHST- 2013/03/27 00:00 [revised]
PHST- 2013/04/16 00:00 [accepted]
PHST- 2013/05/23 06:00 [entrez]
PHST- 2013/05/23 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
AID - S0306-4522(13)00356-4 [pii]
AID - 10.1016/j.neuroscience.2013.04.031 [doi]
PST - ppublish
SO  - Neuroscience. 2013 Oct 10;250:333-41. doi: 10.1016/j.neuroscience.2013.04.031. 
      Epub 2013 May 18.