PMID- 23694989
OWN - NLM
STAT- MEDLINE
DCOM- 20140225
LR  - 20240204
IS  - 0219-1032 (Electronic)
IS  - 1016-8478 (Print)
IS  - 1016-8478 (Linking)
VI  - 35
IP  - 6
DP  - 2013 Jun
TI  - Nutrient regulation of the mTOR complex 1 signaling pathway.
PG  - 463-73
LID - 10.1007/s10059-013-0138-2 [doi]
AB  - The mammalian target of rapamycin (mTOR) is an evolutionally conserved kinase 
      which exists in two distinct structural and functional complexes, mTOR complex 1 
      (mTORC1) and mTOR complex 2 (mTORC2). Of the two complexes, mTORC1 couples 
      nutrient abundance to cell growth and proliferation by sensing and integrating a 
      variety of inputs arising from amino acids, cellular stresses, energy status, and 
      growth factors. Defects in mTORC1 regulation are implicated in the development of 
      many metabolic diseases, including cancer and diabetes. Over the past decade, 
      significant advances have been made in deciphering the complexity of the 
      signaling processes contributing to mTORC1 regulation and function, but the 
      mechanistic details are still not fully understood. In particular, how amino acid 
      availability is sensed by cells and signals to mTORC1 remains unclear. In this 
      review, we discuss the current understanding of nutrient-dependent control of 
      mTORC1 signaling and will focus on the key components involved in amino acid 
      signaling to mTORC1.
FAU - Kim, Sang Gyun
AU  - Kim SG
AD  - Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. 
      SangGyun_Kim@hms.harvard.edu
FAU - Buel, Gwen R
AU  - Buel GR
FAU - Blenis, John
AU  - Blenis J
LA  - eng
GR  - R01 CA046595/CA/NCI NIH HHS/United States
GR  - R01 GM051405/GM/NIGMS NIH HHS/United States
GR  - R01CA46595/CA/NCI NIH HHS/United States
GR  - R01GM51405/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130520
PL  - United States
TA  - Mol Cells
JT  - Molecules and cells
JID - 9610936
RN  - 0 (Amino Acids)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Multiprotein Complexes)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Amino Acids/*metabolism
MH  - Animals
MH  - Energy Metabolism
MH  - Food
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/metabolism
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Mechanistic Target of Rapamycin Complex 2
MH  - Metabolic Diseases/immunology/*metabolism
MH  - Multiprotein Complexes/*metabolism
MH  - Nutritional Physiological Phenomena/immunology
MH  - *Signal Transduction
MH  - Stress, Physiological
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC3887879
EDAT- 2013/05/23 06:00
MHDA- 2014/02/26 06:00
PMCR- 2014/06/30
CRDT- 2013/05/23 06:00
PHST- 2013/05/03 00:00 [received]
PHST- 2013/05/06 00:00 [accepted]
PHST- 2013/05/23 06:00 [entrez]
PHST- 2013/05/23 06:00 [pubmed]
PHST- 2014/02/26 06:00 [medline]
PHST- 2014/06/30 00:00 [pmc-release]
AID - S1016-8478(23)05258-5 [pii]
AID - molcell-35-6-463-1 [pii]
AID - 10.1007/s10059-013-0138-2 [doi]
PST - ppublish
SO  - Mol Cells. 2013 Jun;35(6):463-73. doi: 10.1007/s10059-013-0138-2. Epub 2013 May 
      20.