PMID- 23695291
OWN - NLM
STAT- MEDLINE
DCOM- 20140408
LR  - 20211021
IS  - 1433-0423 (Electronic)
IS  - 0941-293X (Linking)
VI  - 110
IP  - 9
DP  - 2013 Sep
TI  - [Human leukocyte antigen (HLA) system in ophthalmology].
PG  - 849-61
LID - 10.1007/s00347-013-2861-7 [doi]
AB  - Various inflammatory and non-inflammatory eye diseases are associated with 
      specific HLA isotypes. Therefore, HLA isotyping can be a useful diagnostic tool 
      for these diseases and has already been shown to reduce the rejection rate of 
      corneal allografts. Unfortunately, the volume of published data and the varying 
      quality of these publications complicate obtaining good overview in this field. 
      This review briefly summarizes the genetic structure of the HLA system and 
      elucidates differences between HLA classes I and II in the context of antigen 
      presentation. Possible mechanisms of HLA associations in the field of 
      ophthalmology are discussed, and finally different tools (e.g. genome wide 
      association studies) for assessing associations of HLA isotypes with different 
      ocular diseases are examined.
FAU - Lapp, T
AU  - Lapp T
AD  - Division of Infection and Immunity, University College London, UK. 
      T.Lapp@ucl.ac.uk
FAU - Reinhold, D
AU  - Reinhold D
FAU - Bohringer, D
AU  - Bohringer D
FAU - Reinhard, T
AU  - Reinhard T
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Humanes Leukozytenantigensystem in der Augenheilkunde.
PL  - Germany
TA  - Ophthalmologe
JT  - Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
JID - 9206148
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Eye/*immunology
MH  - Eye Diseases/*genetics/*immunology
MH  - Genetic Predisposition to Disease/*genetics
MH  - HLA Antigens/*genetics/*immunology
MH  - Humans
EDAT- 2013/05/23 06:00
MHDA- 2014/04/09 06:00
CRDT- 2013/05/23 06:00
PHST- 2013/05/23 06:00 [entrez]
PHST- 2013/05/23 06:00 [pubmed]
PHST- 2014/04/09 06:00 [medline]
AID - 10.1007/s00347-013-2861-7 [doi]
PST - ppublish
SO  - Ophthalmologe. 2013 Sep;110(9):849-61. doi: 10.1007/s00347-013-2861-7.