PMID- 23697957
OWN - NLM
STAT- MEDLINE
DCOM- 20131106
LR  - 20220410
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Linking)
VI  - 120
IP  - 8
DP  - 2013 Aug
TI  - The posterior pole and papillomacular fold in posterior microphthalmos: novel 
      spectral-domain optical coherence tomography findings.
PG  - 1656-64
LID - S0161-6420(13)00041-9 [pii]
LID - 10.1016/j.ophtha.2013.01.026 [doi]
AB  - PURPOSE: To report and analyze the spectral-domain optical coherence tomography 
      (SD-OCT) features of the posterior pole and papillomacular fold (PMF) in 
      posterior microphthalmos (PM) in relation to axial length of the globe and 
      corneal power. DESIGN: Comparative case series. PARTICIPANTS: Forty eyes of 20 PM 
      patients and 70 eyes of 35 age-matched controls. METHODS: All PM and control eyes 
      underwent a full biometric evaluation, including axial length and corneal power 
      measurements, and macular SD-OCT. In addition, a novel SD-OCT marker of the 
      posterior pole curvature, termed the posterior pole curvature index (PPCI), was 
      measured along both the vertical and horizontal meridians. The OCT 
      characteristics of the PMF were analyzed and the PPCIs were compared and 
      correlated with the axial length and corneal power in both groups of eyes, and 
      with the PMF severity in PM eyes. MAIN OUTCOME MEASURES: We considered the SD-OCT 
      features of the PMF, the PPCI in PM eyes and controls, and the correlations 
      between PPCI and PMF severity and axial length. RESULTS: All PMFs were 
      predominantly horizontal and partial thickness, sparing the outer retina except 
      the outer plexiform layer. The PPCI in PM eyes (mean +/- standard deviation, 
      145+/-40.3 microns; median, 144) was significantly larger than that of controls 
      (14+/-12.8 microns; median, 14; P<0.0001). In addition, the vertical PPCI in PM 
      eyes, but not in controls, was notably larger than the horizontal PPCI (mean 
      difference, 55+/-30.4 microns; P<0.0001). In PM eyes, the PPCI strongly correlated 
      with PMF height (R = 0.68; P<0.0001), inverse axial length (R = -0.71; P<0.0001), 
      and corneal power (R = 0.49; P = 0.002), and the PMF height correlated strongly 
      and inversely with the axial length (R = -0.62; P<0.0001). CONCLUSIONS: The PMF 
      in PM eyes has characteristic morphologic SD-OCT features. The increased 
      posterior pole curvature in PM and its significant correlation with the axial 
      length, the PMF severity and keratometry established in this study suggest that 
      PM eyes are not only shorter than normal, but seem to be abnormally shaped 
      posteriorly, particularly along the vertical meridian. This factor may play a 
      role in the pathogenesis and morphology of the PMF. FINANCIAL DISCLOSURE(S): The 
      authors have no proprietary or commercial interest in any of the materials 
      discussed in this article.
CI  - Copyright (c) 2013 American Academy of Ophthalmology. Published by Elsevier Inc. 
      All rights reserved.
FAU - Nowilaty, Sawsan R
AU  - Nowilaty SR
AD  - Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi 
      Arabia. snowilaty@kkesh.med.sa
FAU - Mousa, Ahmed
AU  - Mousa A
FAU - Ghazi, Nicola G
AU  - Ghazi NG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130519
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Axial Length, Eye/*pathology
MH  - Biometry
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Cornea/*physiopathology
MH  - Female
MH  - Humans
MH  - Hyperopia/physiopathology
MH  - Male
MH  - Microphthalmos/*diagnosis/physiopathology
MH  - Middle Aged
MH  - Refraction, Ocular/physiology
MH  - Retinal Diseases/*diagnosis/physiopathology
MH  - Retrospective Studies
MH  - *Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Young Adult
EDAT- 2013/05/24 06:00
MHDA- 2013/11/07 06:00
CRDT- 2013/05/24 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2013/01/11 00:00 [revised]
PHST- 2013/01/11 00:00 [accepted]
PHST- 2013/05/24 06:00 [entrez]
PHST- 2013/05/24 06:00 [pubmed]
PHST- 2013/11/07 06:00 [medline]
AID - S0161-6420(13)00041-9 [pii]
AID - 10.1016/j.ophtha.2013.01.026 [doi]
PST - ppublish
SO  - Ophthalmology. 2013 Aug;120(8):1656-64. doi: 10.1016/j.ophtha.2013.01.026. Epub 
      2013 May 19.