PMID- 23697980
OWN - NLM
STAT- MEDLINE
DCOM- 20140410
LR  - 20211203
IS  - 1521-0669 (Electronic)
IS  - 0888-0018 (Linking)
VI  - 30
IP  - 7
DP  - 2013 Oct
TI  - The mTOR signaling pathway in pediatric neuroblastoma.
PG  - 605-15
LID - 10.3109/08880018.2013.798058 [doi]
AB  - Neuroblastoma (NB) is the most common extracranial malignant solid tumors of 
      childhood, and the majority of these high-risk tumors is resistant to nearly all 
      the treatments and has a significantly worse outcome. The mammalian target of 
      rapamycin (mTOR) plays a critical role in oncogenesis and cancer progression of 
      many tumors. This review will describe the function of mTOR, its genetic 
      regulation in pediatric neuroblastoma, and its value as a target for inhibition 
      by anticancer agents for patients with NB.
FAU - Mei, Hong
AU  - Mei H
AD  - 1Department of Pediatric Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Wang, Ye
AU  - Wang Y
FAU - Lin, Zhenyu
AU  - Lin Z
FAU - Tong, Qiangsong
AU  - Tong Q
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130522
PL  - England
TA  - Pediatr Hematol Oncol
JT  - Pediatric hematology and oncology
JID - 8700164
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Neoplasm Proteins)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adolescent
MH  - Antineoplastic Agents/therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Drug Delivery Systems/methods
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Neoplasm Proteins/genetics/*metabolism
MH  - Neuroblastoma/drug therapy/genetics/*metabolism/pathology
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
EDAT- 2013/05/24 06:00
MHDA- 2014/04/11 06:00
CRDT- 2013/05/24 06:00
PHST- 2013/05/24 06:00 [entrez]
PHST- 2013/05/24 06:00 [pubmed]
PHST- 2014/04/11 06:00 [medline]
AID - 10.3109/08880018.2013.798058 [doi]
PST - ppublish
SO  - Pediatr Hematol Oncol. 2013 Oct;30(7):605-15. doi: 10.3109/08880018.2013.798058. 
      Epub 2013 May 22.