PMID- 2369898
OWN - NLM
STAT- MEDLINE
DCOM- 19900822
LR  - 20220511
IS  - 0261-4189 (Print)
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Linking)
VI  - 9
IP  - 8
DP  - 1990 Aug
TI  - Regional distribution of brain-derived neurotrophic factor mRNA in the adult 
      mouse brain.
PG  - 2459-64
AB  - Brain-derived neurotrophic factor (BDNF) is a protein that allows the survival of 
      specific neuronal populations. This study reports on the distribution of the BDNF 
      mRNA in the adult mouse brain, where the BDNF gene is strongly expressed, using 
      quantitative Northern blot analysis and in situ hybridization. All brain regions 
      examined were found to contain substantial amounts of BDNF mRNA, the highest 
      levels being found in the hippocampus followed by the cerebral cortex. In the 
      hippocampus, which is also the site of highest nerve growth factor (NGF) gene 
      expression in the central nervous system (CNS), there is approximately 50-fold 
      more BDNF mRNA than NGF mRNA. In other brain regions, such as the granule cell 
      layer of the cerebellum, the differences between the levels of BDNF and NGF mRNAs 
      are even more pronounced. The BDNF mRNA was localized by in situ hybridization in 
      hippocampal neurons (pyramidal and granule cells). These data suggest that BDNF 
      may play an important role in the CNS for a wide variety of adult neurons.
FAU - Hofer, M
AU  - Hofer M
AD  - Max-Planck Institute for Psychiatry, Department of Neurochemistry, Martinsried, 
      FRG.
FAU - Pagliusi, S R
AU  - Pagliusi SR
FAU - Hohn, A
AU  - Hohn A
FAU - Leibrock, J
AU  - Leibrock J
FAU - Barde, Y A
AU  - Barde YA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Phosphorus Radioisotopes)
RN  - 0 (RNA, Messenger)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Autoradiography
MH  - Base Sequence
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor
MH  - Cloning, Molecular
MH  - DNA/genetics
MH  - Gene Library
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/*genetics
MH  - Nerve Tissue Proteins/*genetics
MH  - Organ Specificity
MH  - Phosphorus Radioisotopes
MH  - RNA, Messenger/*analysis/genetics
PMC - PMC552273
EDAT- 1990/08/01 00:00
MHDA- 1990/08/01 00:01
PMCR- 1991/08/01
CRDT- 1990/08/01 00:00
PHST- 1990/08/01 00:00 [pubmed]
PHST- 1990/08/01 00:01 [medline]
PHST- 1990/08/01 00:00 [entrez]
PHST- 1991/08/01 00:00 [pmc-release]
AID - 10.1002/j.1460-2075.1990.tb07423.x [doi]
PST - ppublish
SO  - EMBO J. 1990 Aug;9(8):2459-64. doi: 10.1002/j.1460-2075.1990.tb07423.x.