PMID- 23699532
OWN - NLM
STAT- MEDLINE
DCOM- 20130809
LR  - 20211021
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 33
IP  - 21
DP  - 2013 May 22
TI  - BDNF-dependent recycling facilitates TrkB translocation to postsynaptic density 
      during LTP via a Rab11-dependent pathway.
PG  - 9214-30
LID - 10.1523/JNEUROSCI.3256-12.2013 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) plays an important role in the 
      activity-dependent regulation of synaptic structure and function via tropomyosin 
      related kinase B (TrkB) receptor activation. However, whether BDNF could regulate 
      TrkB levels at synapse during long-term potentiation (LTP) is still unknown. We 
      show in cultured rat hippocampal neurons that chemical LTP (cLTP) stimuli 
      selectively promote endocytic recycling of BDNF-dependent full-length TrkB 
      (TrkB-FL) receptors, but not isoform T1 (TrkB.T1) receptors, via a 
      Rab11-dependent pathway. Moreover, neuronal-activity-enhanced TrkB-FL recycling 
      could facilitate receptor translocation to postsynaptic density and enhance 
      BDNF-induced extracellular signal-regulated kinase and phosphatidylinositol 
      3-kinase activation and rat hippocampal neuron survival. Finally, we found that 
      cLTP could stimulate the switch of Rab11 from an inactive to an active form and 
      that GTP-bound Rab11 could enhance the interaction between TrkB-FL and PSD-95. 
      Therefore, the recycling endosome could serve as a reserve pool to supply TrkB-FL 
      receptors for LTP maintenance. These findings provide a mechanistic link between 
      Rab11-dependent endocytic recycling and TrkB modulation of synaptic plasticity.
FAU - Huang, Shu-Hong
AU  - Huang SH
AD  - Department of Neurobiology, Shandong Provincial Key Laboratory of Mental 
      Disorders, School of Medicine, Shandong University, Jinan, Shandong 250012, PR 
      China.
FAU - Wang, Jue
AU  - Wang J
FAU - Sui, Wen-Hai
AU  - Sui WH
FAU - Chen, Bing
AU  - Chen B
FAU - Zhang, Xiao-Yan
AU  - Zhang XY
FAU - Yan, Jing
AU  - Yan J
FAU - Geng, Zhao
AU  - Geng Z
FAU - Chen, Zhe-Yu
AU  - Chen ZY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Disks Large Homolog 4 Protein)
RN  - 0 (Dlg4 protein, rat)
RN  - 0 (Exoc6 protein, rat)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 3.6.1.- (rab11 protein)
RN  - EC 3.6.5.2 (rab GTP-Binding Proteins)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Biotinylation
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disks Large Homolog 4 Protein
MH  - Electric Stimulation
MH  - Embryo, Mammalian
MH  - Female
MH  - Hippocampus/cytology
MH  - Immunoprecipitation
MH  - In Situ Nick-End Labeling
MH  - In Vitro Techniques
MH  - Intracellular Signaling Peptides and Proteins/metabolism
MH  - Long-Term Potentiation/drug effects/*physiology
MH  - Male
MH  - Membrane Proteins/metabolism
MH  - Neurons/*physiology/ultrastructure
MH  - Patch-Clamp Techniques
MH  - Post-Synaptic Density/genetics/*physiology
MH  - Protein Binding
MH  - Protein Transport/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*metabolism
MH  - Subcellular Fractions/metabolism
MH  - rab GTP-Binding Proteins/genetics/*metabolism
PMC - PMC6705013
EDAT- 2013/05/24 06:00
MHDA- 2013/08/10 06:00
PMCR- 2013/11/22
CRDT- 2013/05/24 06:00
PHST- 2013/05/24 06:00 [entrez]
PHST- 2013/05/24 06:00 [pubmed]
PHST- 2013/08/10 06:00 [medline]
PHST- 2013/11/22 00:00 [pmc-release]
AID - 33/21/9214 [pii]
AID - 3256-12 [pii]
AID - 10.1523/JNEUROSCI.3256-12.2013 [doi]
PST - ppublish
SO  - J Neurosci. 2013 May 22;33(21):9214-30. doi: 10.1523/JNEUROSCI.3256-12.2013.