PMID- 23700463
OWN - NLM
STAT- MEDLINE
DCOM- 20131125
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 5
DP  - 2013
TI  - Manipulation of BDNF signaling modifies the experience-dependent plasticity 
      induced by pure tone exposure during the critical period in the primary auditory 
      cortex.
PG  - e64208
LID - 10.1371/journal.pone.0064208 [doi]
LID - e64208
AB  - Sensory experience powerfully shapes cortical sensory representations during an 
      early developmental "critical period" of plasticity. In the rat primary auditory 
      cortex (A1), the experience-dependent plasticity is exemplified by significant, 
      long-lasting distortions in frequency representation after mere exposure to 
      repetitive frequencies during the second week of life. In the visual system, the 
      normal unfolding of critical period plasticity is strongly dependent on the 
      elaboration of brain-derived neurotrophic factor (BDNF), which promotes the 
      establishment of inhibition. Here, we tested the hypothesis that BDNF signaling 
      plays a role in the experience-dependent plasticity induced by pure tone exposure 
      during the critical period in the primary auditory cortex. Elvax resin implants 
      filled with either a blocking antibody against BDNF or the BDNF protein were 
      placed on the A1 of rat pups throughout the critical period window. These pups 
      were then exposed to 7 kHz pure tone for 7 consecutive days and their frequency 
      representations were mapped. BDNF blockade completely prevented the shaping of 
      cortical tuning by experience and resulted in poor overall frequency tuning in 
      A1. By contrast, BDNF infusion on the developing A1 amplified the effect of 7 kHz 
      tone exposure compared to control. These results indicate that BDNF signaling 
      participates in the experience-dependent plasticity induced by pure tone exposure 
      during the critical period in A1.
FAU - Anomal, Renata
AU  - Anomal R
AD  - W.M. Keck Foundation Center for Integrative Neurosciences, University of 
      California San Francisco, San Francisco, California, USA.
FAU - de Villers-Sidani, Etienne
AU  - de Villers-Sidani E
FAU - Merzenich, Michael M
AU  - Merzenich MM
FAU - Panizzutti, Rogerio
AU  - Panizzutti R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130521
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Receptors, GABA)
SB  - IM
MH  - Acoustic Stimulation
MH  - Animals
MH  - Auditory Cortex/*physiology
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/*metabolism
MH  - *Critical Period, Psychological
MH  - Learning
MH  - Neuronal Plasticity/*physiology
MH  - Rats
MH  - Receptors, GABA/metabolism
MH  - *Signal Transduction
PMC - PMC3660256
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/05/24 06:00
MHDA- 2013/12/16 06:00
PMCR- 2013/05/21
CRDT- 2013/05/24 06:00
PHST- 2012/12/24 00:00 [received]
PHST- 2013/04/10 00:00 [accepted]
PHST- 2013/05/24 06:00 [entrez]
PHST- 2013/05/24 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
PHST- 2013/05/21 00:00 [pmc-release]
AID - PONE-D-13-00032 [pii]
AID - 10.1371/journal.pone.0064208 [doi]
PST - epublish
SO  - PLoS One. 2013 May 21;8(5):e64208. doi: 10.1371/journal.pone.0064208. Print 2013.