PMID- 23700501
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130524
LR  - 20211021
IS  - 2005-6737 (Print)
IS  - 2005-6745 (Electronic)
IS  - 2005-6737 (Linking)
VI  - 54
IP  - 5
DP  - 2013 May
TI  - Effects of mirodenafil, a phosphodiesterase-5 inhibitor, on female rat bladder in 
      a partial bladder outlet obstruction model: physiological and immunohistochemical 
      aspects.
PG  - 339-44
LID - 10.4111/kju.2013.54.5.339 [doi]
AB  - PURPOSE: We investigated the effects of mirodenafil, a phosphodiesterase-5 
      inhibitor developed in South Korea, on the female rat bladder in a partial 
      bladder outlet obstruction (BOO) model. MATERIALS AND METHODS: Thirty-six female 
      Sprague-Dawley rats were divided into four groups: the control group, BOO without 
      medication group, BOO with mirodenafil 1 mg/kg group, and BOO with mirodenafil 4 
      mg/kg group. Mirodenafil was administered orally for 2 weeks after the induction 
      of BOO. Two weeks after BOO, the rats in each group underwent cystometry under 
      urethane anesthesia. After cystometry, the bladder was excised to perform 
      immunohistochemical staining for connexin 43. RESULTS: The three BOO groups 
      showed significant increases in mean bladder weight compared with the control 
      group. Baseline pressure, threshold pressure, and maximum contraction pressure 
      were not significantly different between the four groups. Although the 
      contraction interval was decreased in all BOO groups compared with the control 
      group, it was prolonged in the two groups treated with mirodenafil compared with 
      the untreated BOO group. In the immunohistochemical examination, connexin 43 
      staining intensity in the lamina propria increased in the three BOO groups 
      compared with the control group. The two groups treated with mirodenafil, 
      however, showed decreased connexin 43 staining compared with the untreated BOO 
      group. CONCLUSIONS: Mirodenafil may increase the contraction intervals of female 
      rat bladders in a partial BOO model. Decreasing bladder overactivity by 
      mirodenafil may be related to intracellular communication mechanisms involving 
      connexin 43.
FAU - Kang, Jung Yoon
AU  - Kang JY
AD  - Department of Urology, Eulji General Hospital, Seoul, Korea.
FAU - Kim, Eun Kyung
AU  - Kim EK
FAU - Kim, Kwang Myung
AU  - Kim KM
LA  - eng
PT  - Journal Article
DEP - 20130514
PL  - Korea (South)
TA  - Korean J Urol
JT  - Korean journal of urology
JID - 101499376
PMC - PMC3659229
OTO - NOTNLM
OT  - Connexin 43
OT  - Overactive urinary bladder
OT  - Phosphodiesterase inhibitors
OT  - Urinary bladder neck obstruction
COIS- The authors have nothing to disclose.
EDAT- 2013/05/24 06:00
MHDA- 2013/05/24 06:01
PMCR- 2013/05/01
CRDT- 2013/05/24 06:00
PHST- 2012/12/31 00:00 [received]
PHST- 2013/03/11 00:00 [accepted]
PHST- 2013/05/24 06:00 [entrez]
PHST- 2013/05/24 06:00 [pubmed]
PHST- 2013/05/24 06:01 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - 10.4111/kju.2013.54.5.339 [doi]
PST - ppublish
SO  - Korean J Urol. 2013 May;54(5):339-44. doi: 10.4111/kju.2013.54.5.339. Epub 2013 
      May 14.