PMID- 23701309
OWN - NLM
STAT- MEDLINE
DCOM- 20140218
LR  - 20220410
IS  - 1475-097X (Electronic)
IS  - 1475-0961 (Linking)
VI  - 33
IP  - 5
DP  - 2013 Sep
TI  - Inflammation marker, damage marker and anabolic hormone responses to resistance 
      training with vascular restriction in older males.
PG  - 393-9
LID - 10.1111/cpf.12044 [doi]
AB  - The goal of this study was to examine anabolic hormone, muscle damage marker and 
      inflammation marker responses to two types of resistance training protocols in 
      older men. Thirty-six healthy older males (mean age = 56.6 +/- 0.6 years) completed 
      6 weeks of high-intensity resistance training (HI-RT), low-intensity resistance 
      training with vascular restriction (LI-BFR) or no exercise control group (CON) 
      three times per week. Three upper body exercises were performed by both exercise 
      groups at the same intensity (at 80% 1-RM), but lower body exercises were 
      performed by the HI-RT group at 80% 1-RM and by the LI-BFR group at 20% 1-RM with 
      vascular restriction. Resting serum creatine kinase (CK), interleukin 6 (IL-6), 
      insulin-like growth factor-I (IGF-I), IGF binding protein 3 (IGFBP-3) and 
      testosterone (T) were measured before and after training. No significant group 
      differences in resting CK, IL-6, IGF-I, IGFBP-3 and T were detected following 
      training (P>0.05). In addition, there were no significant changes in muscle 
      cross-sectional area (CSA), but a trend for significant decreases in the percent 
      changes in thigh subcutaneous fat (P = 0.051). Although training-induced anabolic 
      hormone response did not reach statistical significance, our findings on CK and 
      IL-6 indicated that the LI-BFR training protocol was safe and well tolerated for 
      older men to perform to improve muscular strength.
CI  - (c) 2013 Scandinavian Society of Clinical Physiology and Nuclear Medicine. 
      Published by John Wiley & Sons Ltd.
FAU - Karabulut, Murat
AU  - Karabulut M
AD  - Department of Health and Human Performance, University of Texas at Brownsville, 
      Brownsville, TX 78520, USA. murat.karabulut@utb.edu
FAU - Sherk, Vanessa D
AU  - Sherk VD
FAU - Bemben, Debra A
AU  - Bemben DA
FAU - Bemben, Michael G
AU  - Bemben MG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130423
PL  - England
TA  - Clin Physiol Funct Imaging
JT  - Clinical physiology and functional imaging
JID - 101137604
RN  - 0 (Biomarkers)
RN  - 0 (IGF1 protein, human)
RN  - 0 (IGFBP3 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Interleukin-6)
RN  - 3XMK78S47O (Testosterone)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Creatine Kinase/blood
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Interleukin-6/blood
MH  - Lower Extremity/*blood supply
MH  - Male
MH  - Middle Aged
MH  - Muscle Contraction
MH  - Muscle Strength
MH  - Muscle, Skeletal/diagnostic imaging/enzymology/immunology/*metabolism
MH  - Regional Blood Flow
MH  - *Resistance Training/adverse effects
MH  - Testosterone/*blood
MH  - Time Factors
MH  - Tomography, X-Ray Computed
MH  - *Tourniquets/adverse effects
OTO - NOTNLM
OT  - blood flow restriction
OT  - inflammation marker
OT  - muscle damage
OT  - resistance training
OT  - testosterone
EDAT- 2013/05/25 06:00
MHDA- 2014/02/19 06:00
CRDT- 2013/05/25 06:00
PHST- 2013/01/23 00:00 [received]
PHST- 2013/03/27 00:00 [accepted]
PHST- 2013/05/25 06:00 [entrez]
PHST- 2013/05/25 06:00 [pubmed]
PHST- 2014/02/19 06:00 [medline]
AID - 10.1111/cpf.12044 [doi]
PST - ppublish
SO  - Clin Physiol Funct Imaging. 2013 Sep;33(5):393-9. doi: 10.1111/cpf.12044. Epub 
      2013 Apr 23.