PMID- 23701531
OWN - NLM
STAT- MEDLINE
DCOM- 20140225
LR  - 20211021
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 25
IP  - 8
DP  - 2013 Aug
TI  - Physiological regulation of magnocellular neurosecretory cell activity: 
      integration of intrinsic, local and afferent mechanisms.
PG  - 678-710
LID - 10.1111/jne.12051 [doi]
AB  - The hypothalamic supraoptic and paraventricular nuclei contain magnocellular 
      neurosecretory cells (MNCs) that project to the posterior pituitary gland where 
      they secrete either oxytocin or vasopressin (the antidiuretic hormone) into the 
      circulation. Oxytocin is important for delivery at birth and is essential for 
      milk ejection during suckling. Vasopressin primarily promotes water reabsorption 
      in the kidney to maintain body fluid balance, but also increases 
      vasoconstriction. The profile of oxytocin and vasopressin secretion is 
      principally determined by the pattern of action potentials initiated at the cell 
      bodies. Although it has long been known that the activity of MNCs depends upon 
      afferent inputs that relay information on reproductive, osmotic and 
      cardiovascular status, it has recently become clear that activity depends 
      critically on local regulation by glial cells, as well as intrinsic regulation by 
      the MNCs themselves. Here, we provide an overview of recent advances in our 
      understanding of how intrinsic and local extrinsic mechanisms integrate with 
      afferent inputs to generate appropriate physiological regulation of oxytocin and 
      vasopressin MNC activity.
CI  - (c) 2013 British Society for Neuroendocrinology.
FAU - Brown, C H
AU  - Brown CH
AD  - Department of Physiology and Centre for Neuroendocrinology, University of Otago, 
      Dunedin, New Zealand. colin.brown@otago.ac.nz
FAU - Bains, J S
AU  - Bains JS
FAU - Ludwig, M
AU  - Ludwig M
FAU - Stern, J E
AU  - Stern JE
LA  - eng
GR  - R01 HL112225/HL/NHLBI NIH HHS/United States
GR  - R21 HL113801/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 50-56-6 (Oxytocin)
SB  - IM
MH  - *Afferent Pathways
MH  - Animals
MH  - Hypothalamus/cytology/metabolism/physiology
MH  - Neurons/metabolism/*physiology
MH  - Oxytocin/metabolism
MH  - Rats
PMC - PMC3852704
MID - NIHMS485754
OTO - NOTNLM
OT  - osmoregulation
OT  - oxytocin
OT  - paraventricular nucleus
OT  - reproduction
OT  - supraoptic nucleus
OT  - vasopressin
EDAT- 2013/05/25 06:00
MHDA- 2014/02/26 06:00
PMCR- 2014/08/01
CRDT- 2013/05/25 06:00
PHST- 2013/03/31 00:00 [received]
PHST- 2013/05/08 00:00 [revised]
PHST- 2013/05/20 00:00 [accepted]
PHST- 2013/05/25 06:00 [entrez]
PHST- 2013/05/25 06:00 [pubmed]
PHST- 2014/02/26 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - 10.1111/jne.12051 [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2013 Aug;25(8):678-710. doi: 10.1111/jne.12051.