PMID- 23701555
OWN - NLM
STAT- MEDLINE
DCOM- 20141102
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 20
IP  - 6
DP  - 2014
TI  - Flavonoids on allergy.
PG  - 973-87
AB  - Flavonoids are secondary products of plants that include thousands of compounds 
      classified in several classes. Preclinical studies mainly carried out in rodents 
      suggest that they may have a role in the prevention of immunoglobulin E (IgE) 
      synthesis and mast cell degranulation. Interestingly, using animal models with 
      allergic asthma, it can be concluded that preventive treatment with particular 
      flavonoid classes can reduce airway hyperresponsiveness, which is accompanied by 
      lowered inflammatory mediators such as histamine and cytokines, and cell 
      infiltration. In addition, there are some clinical trials in patients with 
      allergic asthma or rhinitis that offer promising results with regard to these 
      natural compounds. On the other hand, the dissection of cellular mechanisms that 
      have interacted with flavonoids allow their effectiveness to be understood. Among 
      these mechanisms there is a lower expression of IgE receptor or other membrane 
      receptors, the modulation of calcium influx, and the downregulation of particular 
      signaling pathways that eventually produces lower primary and secondary mediator 
      release. In conclusion, some particular flavonoids could be an alternative or 
      complementary therapy in the prevention and treatment of some allergies. 
      Nevertheless, an increased number of clinical trials is required in order to 
      confirm the therapeutic role of flavonoids.
FAU - Castell, Margarida
AU  - Castell M
FAU - Perez-Cano, Francisco J
AU  - Perez-Cano FJ
FAU - Abril-Gil, Mar
AU  - Abril-Gil M
FAU - Franch, Angels
AU  - Franch A
AD  - Faculty of Pharmacy, Department of Physiology, Av Joan XXIII s/n, Barcelona 
      E-08028, Spain. margaridacastell@ub.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Flavonoids)
RN  - 0 (Receptors, IgE)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Asthma/immunology/prevention & control
MH  - Disease Models, Animal
MH  - Flavonoids/chemistry/isolation & purification/*pharmacology
MH  - Humans
MH  - Hypersensitivity/immunology/*prevention & control
MH  - Immunoglobulin E/*immunology
MH  - Receptors, IgE/immunology
EDAT- 2013/05/25 06:00
MHDA- 2014/11/05 06:00
CRDT- 2013/05/25 06:00
PHST- 2013/03/19 00:00 [received]
PHST- 2013/05/15 00:00 [accepted]
PHST- 2013/05/25 06:00 [entrez]
PHST- 2013/05/25 06:00 [pubmed]
PHST- 2014/11/05 06:00 [medline]
AID - CPD-EPUB-20130516-17 [pii]
AID - 10.2174/13816128113199990041 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2014;20(6):973-87. doi: 10.2174/13816128113199990041.