PMID- 23701753
OWN - NLM
STAT- MEDLINE
DCOM- 20140320
LR  - 20220409
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Linking)
VI  - 24
IP  - 9
DP  - 2013 Sep
TI  - Retinoid X receptors in macrophage biology.
PG  - 460-8
LID - S1043-2760(13)00078-7 [pii]
LID - 10.1016/j.tem.2013.04.004 [doi]
AB  - Retinoid X receptors (RXRs) form a distinct and unique subclass within the 
      nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs 
      regulate a plethora of genetic programs, including cell differentiation, the 
      immune response, and lipid and glucose metabolism. Recent advances reveal that 
      RXRs are important regulators of macrophages, key players in inflammatory and 
      metabolic disorders. This review outlines the versatility of RXR action in the 
      control of macrophage gene transcription through its heterodimerization with 
      other NRs or through RXR homodimerization. We also highlight the potential of 
      RXR-controlled transcriptional programs as targets for the treatment of 
      pathologies associated with altered macrophage function, such as atherosclerosis, 
      insulin resistance, autoimmunity, and neurodegeneration.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Roszer, Tamas
AU  - Roszer T
AD  - Cardiovascular Development and Repair Department, Centro Nacional de 
      Investigaciones Cardiovasculares (CNIC), Melchor Fernandez Almagro 3, 28029 
      Madrid, Spain.
FAU - Menendez-Gutierrez, Maria P
AU  - Menendez-Gutierrez MP
FAU - Cedenilla, Marta
AU  - Cedenilla M
FAU - Ricote, Mercedes
AU  - Ricote M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130520
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (Retinoid X Receptors)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immunity, Innate/immunology
MH  - Macrophages/*immunology
MH  - Retinoid X Receptors/*immunology
OTO - NOTNLM
OT  - gene transcription
OT  - inflammation
OT  - lipid metabolism
OT  - macrophage
OT  - nuclear receptors
EDAT- 2013/05/25 06:00
MHDA- 2014/03/22 06:00
CRDT- 2013/05/25 06:00
PHST- 2013/02/01 00:00 [received]
PHST- 2013/04/19 00:00 [revised]
PHST- 2013/04/23 00:00 [accepted]
PHST- 2013/05/25 06:00 [entrez]
PHST- 2013/05/25 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
AID - S1043-2760(13)00078-7 [pii]
AID - 10.1016/j.tem.2013.04.004 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2013 Sep;24(9):460-8. doi: 10.1016/j.tem.2013.04.004. 
      Epub 2013 May 20.