PMID- 23702250
OWN - NLM
STAT- MEDLINE
DCOM- 20140404
LR  - 20130813
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 47
IP  - 10
DP  - 2013 Oct
TI  - Serum concentrations of brain-derived neurotrophic factor in patients with gender 
      identity disorder.
PG  - 1546-8
LID - S0022-3956(13)00138-6 [pii]
LID - 10.1016/j.jpsychires.2013.04.012 [doi]
AB  - Gender Identity Disorder (GID) is characterized by a strong and persistent 
      cross-gender identification that affects different aspects of behavior. 
      Brain-derived neurotrophic factor (BDNF) plays a critical role in 
      neurodevelopment and neuroplasticity. Altered BDNF-signaling is thought to 
      contribute to the pathogenesis of psychiatric disordersand is related to 
      traumatic life events. To examine serum BDNF levels, we compared one group of 
      DSM-IV GID patients (n = 45) and one healthy control group (n = 66). Serum BDNF 
      levels were significantly decreased in GID patients (p = 0.013). This data 
      support the hypothesis that the reduction found in serum BDNF levels in GID 
      patients may be related to the psychological abuse that transsexuals are exposed 
      during their life.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Fontanari, Anna-Martha V
AU  - Fontanari AM
AD  - Gender Identity Disorder Program, Hospital de Clinicas de Porto Alegre, 
      Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
FAU - Andreazza, Tahiana
AU  - Andreazza T
FAU - Costa, Angelo B
AU  - Costa AB
FAU - Salvador, Jaqueline
AU  - Salvador J
FAU - Koff, Walter J
AU  - Koff WJ
FAU - Aguiar, Bianca
AU  - Aguiar B
FAU - Ferrari, Pamela
AU  - Ferrari P
FAU - Massuda, Raffael
AU  - Massuda R
FAU - Pedrini, Mariana
AU  - Pedrini M
FAU - Silveira, Esalba
AU  - Silveira E
FAU - Belmonte-de-Abreu, Paulo S
AU  - Belmonte-de-Abreu PS
FAU - Gama, Clarissa S
AU  - Gama CS
FAU - Kauer-Sant'Anna, Marcia
AU  - Kauer-Sant'Anna M
FAU - Kapczinski, Flavio
AU  - Kapczinski F
FAU - Lobato, Maria Ines R
AU  - Lobato MI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130520
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - *Gender Identity
MH  - Humans
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Transsexualism/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Gender identity disorder
OT  - Transsexualism
EDAT- 2013/05/25 06:00
MHDA- 2014/04/05 06:00
CRDT- 2013/05/25 06:00
PHST- 2012/11/13 00:00 [received]
PHST- 2013/04/18 00:00 [revised]
PHST- 2013/04/19 00:00 [accepted]
PHST- 2013/05/25 06:00 [entrez]
PHST- 2013/05/25 06:00 [pubmed]
PHST- 2014/04/05 06:00 [medline]
AID - S0022-3956(13)00138-6 [pii]
AID - 10.1016/j.jpsychires.2013.04.012 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2013 Oct;47(10):1546-8. doi: 10.1016/j.jpsychires.2013.04.012. 
      Epub 2013 May 20.