PMID- 23703297
OWN - NLM
STAT- MEDLINE
DCOM- 20140305
LR  - 20220409
IS  - 1573-7373 (Electronic)
IS  - 0167-594X (Linking)
VI  - 114
IP  - 1
DP  - 2013 Aug
TI  - Caloric restriction reduces edema and prolongs survival in a mouse glioma model.
PG  - 25-32
LID - 10.1007/s11060-013-1154-y [doi]
AB  - Regardless of their cell type of origin, all aggressive brain tumors, such as 
      malignant gliomas and metastatic tumors produce brain edema, which is an 
      important cause of patient morbidity and mortality. Caloric restriction (CR) has 
      long been recognized as a natural therapy that improves health, promotes 
      longevity, and significantly reduces both the incidence and growth of many tumor 
      types. The aim of present work was to investigate the effect of CR on edema and 
      survival in the mice implanted with U87 gliomas. We found that CR significantly 
      inhibited the intracerebral tumor growth, attenuated brain edema, and ultimately 
      prolonged survival of mice with U87 gliomas. Plasma corticosterone level was 
      found higher and serum VEGF and IGF-1 levels were found lower in CR, when 
      compared to AL group. CR upregulated tight junction proteins including claudin-1, 
      claudin-5 and ZO-1, downregulated VEGF and VEGFR2, enhanced alpha-SMA expression, and 
      reduced AQP1 expression in U87 gliomas. In addition, CR suppressed inducible 
      nitric oxide synthase (iNOS) expression and nitric oxide (NO) formation in U87 
      gliomas. In conclusion, CR attenuated edema in U87 orthotopic mouse glioma model 
      associated with elevation of corticosterone, suppression of VEGF/VEGFR2, 
      improvement of tight junctions, and suppression of iNOS expression and NO 
      formation. Our results suggested that CR might be an effective therapy for 
      recurrent malignant brain cancers through alleviating associated edema.
FAU - Jiang, Yong-Sheng
AU  - Jiang YS
AD  - Center of Tumor, Tongji Hospital of Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, People's Republic of China.
FAU - Wang, Fu-Rong
AU  - Wang FR
LA  - eng
PT  - Journal Article
DEP - 20130524
PL  - United States
TA  - J Neurooncol
JT  - Journal of neuro-oncology
JID - 8309335
RN  - 0 (Nitrates)
RN  - 0 (Tight Junction Proteins)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - IY9XDZ35W2 (Glucose)
RN  - TZP1275679 (3-Hydroxybutyric Acid)
SB  - IM
MH  - 3-Hydroxybutyric Acid/blood
MH  - Animals
MH  - Brain Edema/*etiology
MH  - *Brain Neoplasms/blood/complications/mortality/therapy
MH  - Caloric Restriction/*methods
MH  - Cell Line, Tumor
MH  - Disease Models, Animal
MH  - Gene Expression Regulation, Neoplastic/physiology
MH  - *Glioma/blood/complications/mortality/therapy
MH  - Glucose/metabolism
MH  - Insulin-Like Growth Factor I/metabolism
MH  - Lactic Acid/blood
MH  - Male
MH  - Mice
MH  - Nitrates/metabolism
MH  - Permeability
MH  - Statistics, Nonparametric
MH  - Survival Analysis
MH  - Tight Junction Proteins/genetics/metabolism
MH  - Time Factors
MH  - Vascular Endothelial Growth Factor A/blood
EDAT- 2013/05/25 06:00
MHDA- 2014/03/07 06:00
CRDT- 2013/05/25 06:00
PHST- 2012/09/17 00:00 [received]
PHST- 2013/05/12 00:00 [accepted]
PHST- 2013/05/25 06:00 [entrez]
PHST- 2013/05/25 06:00 [pubmed]
PHST- 2014/03/07 06:00 [medline]
AID - 10.1007/s11060-013-1154-y [doi]
PST - ppublish
SO  - J Neurooncol. 2013 Aug;114(1):25-32. doi: 10.1007/s11060-013-1154-y. Epub 2013 
      May 24.