PMID- 23707639
OWN - NLM
STAT- MEDLINE
DCOM- 20140806
LR  - 20211021
IS  - 1873-7064 (Electronic)
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 76 Pt C
IP  - 0 0
DP  - 2014 Jan
TI  - Transcript specificity in BDNF-regulated protein synthesis.
PG  - 657-63
LID - S0028-3908(13)00213-X [pii]
LID - 10.1016/j.neuropharm.2013.05.004 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a critical activity-dependent 
      modulator of gene expression, which can regulate both transcription and 
      translation. Several functions of BDNF, including the induction of dendrite 
      outgrowth and long-term synaptic plasticity, are known to depend, in particular, 
      upon the ability of BDNF to regulate protein synthesis. Although BDNF modestly 
      increases total neuronal protein synthesis, substantial evidence indicates that 
      BDNF induces the translation of only a small subset of expressed mRNAs and 
      demonstrates an extraordinary degree of transcript specificity. The mechanism by 
      which BDNF selectively upregulates the translation of only a discrete group of 
      mRNAs is of intrinsic importance to its trophic function in promoting neuronal 
      growth and plasticity, and is the focus of this review. This article is part of 
      the Special Issue entitled 'BDNF Regulation of Synaptic Structure, Function, and 
      Plasticity'.
CI  - Copyright (c) 2013 Elsevier Ltd. All rights reserved.
FAU - Ruiz, Claudia R
AU  - Ruiz CR
AD  - Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School 
      of Medicine, Baltimore, MD 21205, USA.
FAU - Shi, Jay
AU  - Shi J
FAU - Meffert, Mollie K
AU  - Meffert MK
LA  - eng
GR  - F31 MH098634/MH/NIMH NIH HHS/United States
GR  - R01 MH080740/MH/NIMH NIH HHS/United States
GR  - T32 EY017203/EY/NEI NIH HHS/United States
GR  - MH098634/MH/NIMH NIH HHS/United States
GR  - R01 MH098016/MH/NIMH NIH HHS/United States
GR  - MH098016/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130522
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (MicroRNAs)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism/pharmacology
MH  - Humans
MH  - MicroRNAs/genetics/metabolism
MH  - Neurons/drug effects/metabolism
MH  - Protein Biosynthesis/drug effects/*physiology
MH  - RNA, Messenger/metabolism
PMC - PMC3795894
MID - NIHMS484592
OTO - NOTNLM
OT  - BDNF
OT  - Let-7
OT  - Lin28
OT  - Post-transcriptional regulators
OT  - Protein synthesis
OT  - RNA-binding proteins
OT  - Synaptic plasticity
OT  - microRNAs
EDAT- 2013/05/28 06:00
MHDA- 2014/08/07 06:00
PMCR- 2015/01/01
CRDT- 2013/05/28 06:00
PHST- 2012/12/31 00:00 [received]
PHST- 2013/04/26 00:00 [revised]
PHST- 2013/05/03 00:00 [accepted]
PHST- 2013/05/28 06:00 [entrez]
PHST- 2013/05/28 06:00 [pubmed]
PHST- 2014/08/07 06:00 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - S0028-3908(13)00213-X [pii]
AID - 10.1016/j.neuropharm.2013.05.004 [doi]
PST - ppublish
SO  - Neuropharmacology. 2014 Jan;76 Pt C(0 0):657-63. doi: 
      10.1016/j.neuropharm.2013.05.004. Epub 2013 May 22.