PMID- 23710918
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20201209
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 42
IP  - 2
DP  - 2013 Feb
TI  - [Expression of astrocyte elevated gene-1 protein and its clinical significance in 
      laryngeal squamous cell carcinoma].
PG  - 111-5
LID - 10.3760/cma.j.issn.0529-5807.2013.02.009 [doi]
AB  - OBJECTIVE: To assess the protein expression of astrocyte elevated gene-1 (AEG-1) 
      in tissue specimens of laryngeal squamous cell carcinoma (LSCC), and to correlate 
      its expression with clinicopathological parameters and prognosis in patients with 
      LSCC. METHODS: RT-PCR was used to assay the expression of AEG-1 mRNA in 13 pairs 
      of LSCC tissues and their corresponding noncarcinoma epithelia. 
      Immunohistochemistry was performed on paraffin-embedded tissue specimens to 
      investigate the protein expression of AEG-1 in 88 cases of LSCC specimens and 15 
      cases of adjacent epithelial samples. RESULTS: The expression of AEG-1 mRNA was 
      significantly increased in LSCC tissues compared to adjacent noncarcinoma 
      epithelial tissues (0.81 +/- 0.17 vs. 0.23 +/- 0.10;t = 10.337, P < 0.001). Meantime, 
      the positive rate of AEG-1 protein in 88 cases of LSCC was 87.5% (77/88). 
      However, 15 cases of adjacent noncarcinoma epithelial merely demonstrated 
      negative or mild expression of AEG-1 protein. AEG-1 overexpression was closely 
      correlated with T stage (chi(2) = 6.289, P = 0.018), clinical stage (chi(2) = 11.049, 
      P < 0.01), metastasis (chi(2) = 20.859, P < 0.01) and recurrence(chi(2) = 13.459, P < 
      0.01). The overall survival rates of patients with AEG-1 overexpression and low 
      expression were 35.9% and 86.4%, respectively (chi(2) = 23.409, P < 0.01). 
      Multivariate Cox regression analysis revealed that AEG-1 expression was an 
      independent prognostic factor (P = 0.016). CONCLUSION: AEG-1 protein may play a 
      critical role in the initiation and progression of LSCC, implicating its 
      predictive value in prognosis.
FAU - Liu, Yong
AU  - Liu Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Central South 
      University, Changsha, China.
FAU - Li, Guo
AU  - Li G
FAU - Su, Zhong-wu
AU  - Su ZW
FAU - Qiu, Yuan-zheng
AU  - Qiu YZ
FAU - Zhang, Xin
AU  - Zhang X
FAU - Yu, Chang-yun
AU  - Yu CY
FAU - Zhou, Xiao-juan
AU  - Zhou XJ
FAU - Ren, Shu-ling
AU  - Ren SL
FAU - Huang, Dong-hai
AU  - Huang DH
FAU - Tian, Yong-quan
AU  - Tian YQ
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (MTDH protein, human)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/genetics/*metabolism/*pathology/surgery
MH  - Cell Adhesion Molecules/genetics/*metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Laryngeal Neoplasms/genetics/*metabolism/*pathology/surgery
MH  - Lymphatic Metastasis
MH  - Male
MH  - Membrane Proteins
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Proportional Hazards Models
MH  - RNA, Messenger/metabolism
MH  - RNA-Binding Proteins
MH  - Survival Rate
EDAT- 2013/05/29 06:00
MHDA- 2013/09/17 06:00
CRDT- 2013/05/29 06:00
PHST- 2013/05/29 06:00 [entrez]
PHST- 2013/05/29 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
AID - 10.3760/cma.j.issn.0529-5807.2013.02.009 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2013 Feb;42(2):111-5. doi: 
      10.3760/cma.j.issn.0529-5807.2013.02.009.