PMID- 23711122
OWN - NLM
STAT- MEDLINE
DCOM- 20140110
LR  - 20221207
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 43
IP  - 6
DP  - 2013 Jun
TI  - Smoking attenuates the age-related decrease in IgE levels and maintains 
      eosinophilic inflammation.
PG  - 608-15
LID - 10.1111/cea.12073 [doi]
AB  - BACKGROUND: Epidemiological studies have shown that smoking increases the 
      propensity for atopy and asthma. However, the effects of smoking on atopy and 
      eosinophilic inflammation in asthmatics, including the elderly, remain unknown. 
      OBJECTIVE: To determine the effects of smoking on serum immunoglobulin E (IgE) 
      levels and eosinophilic inflammation in asthmatics of all ages. METHODS: The 
      associations of serum IgE levels, blood eosinophil counts and fractional exhaled 
      nitric oxide (FeNO) levels with smoking and age in steroid-naive asthmatics were 
      cross-sectionally assessed (n = 307). Levels of sputum eosinophil and thymic 
      stromal lymphopoietin (TSLP) that promotes Th2 inflammation were also analysed. 
      Current smokers were excluded when analysing contributing factors of FeNO. 
      RESULTS: Levels of serum IgE, blood eosinophil and FeNO decreased with increasing 
      age in never-smokers, whereas decrease in serum IgE levels with increasing age 
      was not observed in current smokers. In addition, current smoking was associated 
      with higher blood eosinophil counts. In atopic asthmatics, age-related declines 
      in serum IgE levels were less steep in ex-smokers than in never-smokers, and 
      atopic ex-smokers with asthma showed higher blood eosinophil counts and higher 
      FeNO irrespective of age. Lastly, sputum TSLP levels were associated with sputum 
      eosinophil proportions and pack-years. Current and ex-smokers had higher TSLP 
      levels than never-smokers. CONCLUSIONS AND CLINICAL RELEVANCE: In steroid-naive 
      asthmatics, smoking may attenuate the age-related decrease in IgE levels and 
      maintain eosinophilic inflammation, in which TSLP may be involved.
CI  - (c) 2012 John Wiley & Sons Ltd.
FAU - Nagasaki, T
AU  - Nagasaki T
AD  - Department of Respiratory Medicine, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
FAU - Matsumoto, H
AU  - Matsumoto H
FAU - Nakaji, H
AU  - Nakaji H
FAU - Niimi, A
AU  - Niimi A
FAU - Ito, I
AU  - Ito I
FAU - Oguma, T
AU  - Oguma T
FAU - Muro, S
AU  - Muro S
FAU - Inoue, H
AU  - Inoue H
FAU - Iwata, T
AU  - Iwata T
FAU - Tajiri, T
AU  - Tajiri T
FAU - Kanemitsu, Y
AU  - Kanemitsu Y
FAU - Mishima, M
AU  - Mishima M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Cytokines)
RN  - 0 (Ferric Compounds)
RN  - 0 (Nitrates)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - N8H8402XOB (ferric nitrate)
RN  - GT0IL38SP4 (Thymic Stromal Lymphopoietin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Asthma/immunology/metabolism
MH  - Cross-Sectional Studies
MH  - Cytokines/metabolism
MH  - Eosinophils/*immunology
MH  - Exhalation
MH  - Female
MH  - Ferric Compounds/blood
MH  - Humans
MH  - Immunoglobulin E/blood/*immunology
MH  - Inflammation/blood/*immunology
MH  - Leukocyte Count
MH  - Male
MH  - Middle Aged
MH  - Nitrates/blood
MH  - Nitric Oxide
MH  - *Smoking
MH  - Sputum/metabolism
MH  - Young Adult
MH  - Thymic Stromal Lymphopoietin
EDAT- 2013/05/29 06:00
MHDA- 2014/01/11 06:00
CRDT- 2013/05/29 06:00
PHST- 2012/08/20 00:00 [received]
PHST- 2012/11/08 00:00 [revised]
PHST- 2012/11/27 00:00 [accepted]
PHST- 2013/05/29 06:00 [entrez]
PHST- 2013/05/29 06:00 [pubmed]
PHST- 2014/01/11 06:00 [medline]
AID - 10.1111/cea.12073 [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2013 Jun;43(6):608-15. doi: 10.1111/cea.12073.