PMID- 23711768
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20211021
IS  - 1878-5891 (Electronic)
IS  - 0378-5955 (Print)
IS  - 0378-5955 (Linking)
VI  - 302
DP  - 2013 Aug
TI  - 'Ecstasy' enhances noise-induced hearing loss.
PG  - 96-106
LID - S0378-5955(13)00137-8 [pii]
LID - 10.1016/j.heares.2013.05.007 [doi]
AB  - 'Ecstasy' or 3,4-methylenedioxy-N-methamphetamine (MDMA) is an amphetamine abused 
      for its euphoric, empathogenic, hallucinatory, and stimulant effects. It is also 
      used to treat certain psychiatric disorders. Common settings for Ecstasy use are 
      nightclubs and "rave" parties where participants consume MDMA and dance to loud 
      music. One concern with the club setting is that exposure to loud sounds can 
      cause permanent sensorineural hearing loss. Another concern is that consumption 
      of MDMA may enhance such hearing loss. Whereas this latter possibility has not 
      been investigated, this study tested the hypothesis that MDMA enhances 
      noise-induced hearing loss (NIHL) by exposing rats to either MDMA, noise trauma, 
      both MDMA and noise, or neither treatment. MDMA was given in a binge pattern of 5 
      mg/kg per intraperitoneal injections every 2 h for a total of four injections to 
      animals in the two MDMA-treated groups (MDMA-only and Noise + MDMA). Saline 
      injections were given to the animals in the two non-MDMA groups (Control and 
      Noise-only). Following the final injection, noise trauma was induced by a 10 kHz 
      tone at 120 dB SPL for 1 h to animals in the two noise trauma-treated groups 
      (Noise-only and Noise + MDMA). Hearing loss was assessed by the auditory 
      brainstem response (ABR) and cochlear histology. Results showed that MDMA 
      enhanced NIHL compared to Noise-only and that MDMA alone caused no hearing loss. 
      This implies that "clubbers" and "rave-goers" are exacerbating the amount of NIHL 
      when they consume MDMA and listen to loud sounds. In contrast to earlier reports, 
      the present study found that MDMA by itself caused no changes in the click-evoked 
      ABR's wave latencies or amplitudes.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Church, Michael W
AU  - Church MW
AD  - Department of Otolaryngology & Head Neck Surgery, Wayne State University School 
      of Medicine, Detroit, MI 48201, USA. mchurch@med.wayne.edu
FAU - Zhang, Jinsheng S
AU  - Zhang JS
FAU - Langford, Megan M
AU  - Langford MM
FAU - Perrine, Shane A
AU  - Perrine SA
LA  - eng
GR  - R25GM58905-10/GM/NIGMS NIH HHS/United States
GR  - R25 GM058905/GM/NIGMS NIH HHS/United States
GR  - P30 DC005188/DC/NIDCD NIH HHS/United States
GR  - 5P30DC005188-10/DC/NIDCD NIH HHS/United States
GR  - K01DA024760-05/DA/NIDA NIH HHS/United States
GR  - K01 DA024760/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130525
PL  - Netherlands
TA  - Hear Res
JT  - Hearing research
JID - 7900445
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 9G34HU7RV0 (Edetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/adverse effects
MH  - Animals
MH  - Auditory Threshold/drug effects/physiology
MH  - Body Temperature
MH  - Cochlea/physiopathology
MH  - Edetic Acid/chemistry
MH  - Evoked Potentials, Auditory, Brain Stem/*drug effects
MH  - Hair Cells, Auditory, Inner/drug effects
MH  - Hair Cells, Auditory, Outer/drug effects
MH  - Hearing Loss, Noise-Induced/chemically induced/*pathology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Noise
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC3748725
MID - NIHMS485520
COIS- Disclosure Statement There are no conflicts of interest to report.
EDAT- 2013/05/29 06:00
MHDA- 2014/02/04 06:00
PMCR- 2014/08/01
CRDT- 2013/05/29 06:00
PHST- 2013/04/09 00:00 [received]
PHST- 2013/05/07 00:00 [revised]
PHST- 2013/05/15 00:00 [accepted]
PHST- 2013/05/29 06:00 [entrez]
PHST- 2013/05/29 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - S0378-5955(13)00137-8 [pii]
AID - 10.1016/j.heares.2013.05.007 [doi]
PST - ppublish
SO  - Hear Res. 2013 Aug;302:96-106. doi: 10.1016/j.heares.2013.05.007. Epub 2013 May 
      25.