PMID- 23711866
OWN - NLM
STAT- MEDLINE
DCOM- 20130724
LR  - 20130528
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 161 Suppl 2
DP  - 2013
TI  - Total and antigen- (fungi, mites and staphylococcal enterotoxins) specific IgEs 
      in nasal polyps is related to local eosinophilic inflammation.
PG  - 147-53
LID - 10.1159/000350387 [doi]
AB  - BACKGROUND: Total and specific immunoglobulin E (IgE) in nasal polyps (NP) is 
      related to local eosinophilic inflammation. However, it remains unclear which 
      antigens cause a stronger accumulation of eosinophils in NP. We investigated 
      whether local IgEs to specific antigens correlated with local eosinophil 
      accumulation. METHODS: Total IgE, antigen-specific IgEs [5 species of fungi, 
      staphylococcal enterotoxins A and B (SEA and SEB), cedar pollen, ragweed pollen 
      and house-dust mites] and eosinophil cationic protein (ECP) were measured in 
      sinus mucosa homogenates and serum from 29 patients with chronic rhinosinusitis 
      with NP (CRSwNP), 8 patients with allergic fungal rhinosinusitis (AFRS) and 8 
      control subjects without CRS. The level of ECP in NP was analyzed for 
      correlations with the total and specific IgE levels in the serum and NP. RESULTS: 
      In CRSwNP, antigen-specific IgEs [Alternaria > mite (Dp) > Aspergillus > SEB > 
      Penicillium > mite (Df), but not the other fungi, SEA or pollens] in the sinus 
      mucosa correlated significantly with the local ECP. In AFRS, antigen-specific 
      IgEs [Penicillium > mite (Df) > Alternaria, but not the other fungi, SEs or 
      pollens] in the sinus mucosa correlated significantly with the local ECP. 
      CONCLUSIONS: Local total IgE and antigen (fungi, mites and SEs)-specific IgEs in 
      NP are related to the local eosinophilic inflammation of AFRS and CRSwNP.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Matsuwaki, Yoshinori
AU  - Matsuwaki Y
AD  - Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, 
      Japan. matuwaki@jikei.ac.jp
FAU - Uno, Keisuke
AU  - Uno K
FAU - Okushi, Tetsushi
AU  - Okushi T
FAU - Otori, Nobuyoshi
AU  - Otori N
FAU - Moriyama, Hiroshi
AU  - Moriyama H
LA  - eng
PT  - Journal Article
DEP - 20130529
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Antigens)
RN  - 0 (Enterotoxins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 39424-53-8 (enterotoxin B, staphylococcal)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Antigens/*immunology
MH  - Enterotoxins/immunology
MH  - Eosinophils/*immunology
MH  - Female
MH  - Fungi/immunology
MH  - Humans
MH  - Immunoglobulin E/blood/*immunology
MH  - Inflammation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Mites/immunology
MH  - Nasal Polyps/*immunology
MH  - Rhinitis/immunology
MH  - Sinusitis/immunology
EDAT- 2013/06/05 06:00
MHDA- 2013/07/25 06:00
CRDT- 2013/05/29 06:00
PHST- 2013/05/29 06:00 [entrez]
PHST- 2013/06/05 06:00 [pubmed]
PHST- 2013/07/25 06:00 [medline]
AID - 000350387 [pii]
AID - 10.1159/000350387 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2013;161 Suppl 2:147-53. doi: 10.1159/000350387. Epub 
      2013 May 29.