PMID- 23711953
OWN - NLM
STAT- MEDLINE
DCOM- 20140102
LR  - 20130611
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 125
IP  - 2
DP  - 2013
TI  - Decreased expression of miR-133a but not of miR-1 is associated with signs of 
      heart failure in patients undergoing coronary bypass surgery.
PG  - 125-30
LID - 10.1159/000348563 [doi]
AB  - OBJECTIVES: Coronary artery disease (CAD)-associated ischemic heart failure is 
      characterized by dysregulated gene expression which is partly mediated by 
      microRNAs (miRNAs). While the muscle-specific miR-1 and miR-133 are involved in 
      cardiac development and hypertrophy, their role in heart failure resulting from 
      CAD is unknown. We, therefore, tested the hypothesis that cardiac miR-1 and 
      miR-133 expression is associated with signs of heart failure in patients 
      undergoing coronary artery bypass grafting. METHODS: 83 patients were included in 
      this prospective study. Cardiac index and vascular pressures were measured under 
      general anesthesia and the miRNA expression was quantified (RNase protection 
      assay and real-time PCR) from samples of the right atrial myocardium. RESULTS: 
      miR-133 expression decreased significantly with increased severity of heart 
      failure, as indicated by a greater New York Heart Association (NYHA) functional 
      class (p = 0.014) and increased pulmonary artery occlusion pressure (p = 0.045). 
      Furthermore, patients with NT-proBNP concentrations >1,800 pg/ml showed a 25% 
      decrease in miR-133 expression compared to patients with concentrations <300 
      pg/ml (p = 0.023). In contrast, no associations were detected for miR-1 
      expression. CONCLUSIONS: In surgical CAD patients, a decreased miR-133 expression 
      is associated with variables characteristic of heart failure. This supports a 
      role for miR-133 but not miR-1 in the adaption to and/or remodeling of the 
      ischemic heart.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Danowski, Nina
AU  - Danowski N
AD  - Institut fur Pharmakogenetik, Universitat Duisburg-Essen und Universitatsklinikum 
      Essen, Essen, Germany.
FAU - Manthey, Iris
AU  - Manthey I
FAU - Jakob, Heinz Gunther
AU  - Jakob HG
FAU - Siffert, Winfried
AU  - Siffert W
FAU - Peters, Jurgen
AU  - Peters J
FAU - Frey, Ulrich H
AU  - Frey UH
LA  - eng
PT  - Journal Article
DEP - 20130524
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
RN  - 0 (MIRN1 microRNA, human)
RN  - 0 (MIRN133 microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Aged
MH  - *Coronary Artery Bypass
MH  - Coronary Artery Disease/complications/*metabolism/surgery
MH  - Heart Failure/etiology/*metabolism
MH  - Humans
MH  - MicroRNAs/*metabolism
MH  - Middle Aged
MH  - Myocardium/metabolism
EDAT- 2013/05/29 06:00
MHDA- 2014/01/03 06:00
CRDT- 2013/05/29 06:00
PHST- 2012/03/18 00:00 [received]
PHST- 2013/01/28 00:00 [accepted]
PHST- 2013/05/29 06:00 [entrez]
PHST- 2013/05/29 06:00 [pubmed]
PHST- 2014/01/03 06:00 [medline]
AID - 000348563 [pii]
AID - 10.1159/000348563 [doi]
PST - ppublish
SO  - Cardiology. 2013;125(2):125-30. doi: 10.1159/000348563. Epub 2013 May 24.