PMID- 23712415
OWN - NLM
STAT- MEDLINE
DCOM- 20140224
LR  - 20171116
IS  - 1097-0010 (Electronic)
IS  - 0022-5142 (Linking)
VI  - 93
IP  - 13
DP  - 2013 Oct
TI  - Short-term and long-term effects of excessive consumption of saturated fats 
      and/or sucrose on metabolic variables in Sprague Dawley rats: a pilot study.
PG  - 3191-7
LID - 10.1002/jsfa.6240 [doi]
AB  - BACKGROUND: Feeding high-fat and/or high-sugar diets to rats leads to a change in 
      markers of metabolic syndrome. However, types and amounts of fat and sugar as 
      well as the length of the experiment for establishing diet-induced metabolic 
      syndrome in the Sprague Dawley (SD) rat model remain uncertain. This study was 
      designed to investigate the effects in SD rats of consuming excess lard, sucrose 
      or a combination of lard and sucrose for a short (4 week) or long (8 week) period 
      of time. RESULTS: Consumption of the high-fat high-sugar (HFHS) diet 
      significantly increased weight gain and abdominal fat weights (P < 0.05), and the 
      rats also began to develop signs of impaired glucose tolerance and had increased 
      fasting blood lipids glucose and insulin concentrations. The high-fat (HF) diet 
      mainly affected weight gain and fat deposition, whereas the high-sugar (HS) diet 
      induced glucose intolerance but not the obesity-related parameters. Control rats 
      showed a tendency towards insulin resistance and glucose intolerance when fed for 
      a long-term period. CONCLUSION: The lard plus sucrose-based HFHS diet is the most 
      efficient one for inducing signs of metabolic syndrome, and SD rats fed this diet 
      for 8 weeks successfully develop obesity and insulin resistance, which can be 
      used as a model for metabolic syndrome research.
CI  - (c) 2013 Society of Chemical Industry.
FAU - Pranprawit, Araya
AU  - Pranprawit A
AD  - Institute of Food, Nutrition and Human Health, Massey University, Palmerston 
      North, New Zealand.
FAU - Wolber, Frances M
AU  - Wolber FM
FAU - Heyes, Julian A
AU  - Heyes JA
FAU - Molan, Abdul L
AU  - Molan AL
FAU - Kruger, Marlena C
AU  - Kruger MC
LA  - eng
PT  - Journal Article
DEP - 20130704
PL  - England
TA  - J Sci Food Agric
JT  - Journal of the science of food and agriculture
JID - 0376334
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Fats)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - SI6O3IW77Z (lard)
SB  - IM
MH  - Abdominal Fat/pathology
MH  - Animals
MH  - Blood Glucose/analysis
MH  - Body Composition
MH  - Diet, High-Fat/*adverse effects
MH  - Dietary Fats
MH  - Dietary Sucrose/*administration & dosage/*adverse effects
MH  - Disease Models, Animal
MH  - Glucose Intolerance/etiology
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Lipids/blood
MH  - Male
MH  - Metabolic Syndrome/*etiology/pathology
MH  - Obesity/etiology
MH  - Organ Size
MH  - Pilot Projects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
MH  - Weight Gain
OTO - NOTNLM
OT  - diet
OT  - fat
OT  - metabolic syndrome
OT  - rat model
OT  - sugar
EDAT- 2013/05/29 06:00
MHDA- 2014/02/25 06:00
CRDT- 2013/05/29 06:00
PHST- 2013/03/08 00:00 [received]
PHST- 2013/05/16 00:00 [revised]
PHST- 2013/05/24 00:00 [accepted]
PHST- 2013/05/29 06:00 [entrez]
PHST- 2013/05/29 06:00 [pubmed]
PHST- 2014/02/25 06:00 [medline]
AID - 10.1002/jsfa.6240 [doi]
PST - ppublish
SO  - J Sci Food Agric. 2013 Oct;93(13):3191-7. doi: 10.1002/jsfa.6240. Epub 2013 Jul 
      4.