PMID- 23713008
OWN - NLM
STAT- MEDLINE
DCOM- 20140324
LR  - 20130823
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 21
IP  - 8
DP  - 2013 Aug
TI  - Longitudinal dynamics of body weight change in the development of type 2 
      diabetes.
PG  - 1643-9
LID - 10.1002/oby.20292 [doi]
AB  - OBJECTIVE: The aim of this study was to test the obesity-type 2 diabetes mellitus 
      (T2DM) link in the context of longitudinal changes in body weight during the 
      progression to diabetes in mature adult nonhuman primates (NHP). DESIGN AND 
      METHODS: A colony of 245 adult rhesus monkeys aged 8-41 years with 179 males were 
      used to define overweight in males as a body weight: >/=13.5 kg or body fat (BF) 
      >/=18% and obesity as >/=16.5 kg or BF >/=27%, and overweight in nonpregnant females 
      was identified as a body weight >8.5 kg or BF >21% and obesity as >/=10.5 kg or BF 
      >/=30%. A subgroup of 48 males (24 T2DM and 24 age-matched non-T2DM) males were 
      studied before and following the onset of overt T2DM for the effects of changes 
      in body weight and obesity in inducing this conversion to overt T2DM. RESULTS: 
      Three years before overt T2DM, mean body weight was 18.4 +/- 3.3 kg. The 
      DM-destined group body weight was 3.2 +/- 1.1 kg greater and had a longer duration 
      and greater severity of obesity, with peak body weight reached at 3.2 +/- 1.8 years 
      before overt T2DM. At DM onset the two groups did not differ significantly in 
      body weight or adiposity. CONCLUSIONS: The natural progression from pre-DM to 
      overt T2DM is caused neither by the amount of excess body weight at DM onset nor 
      by the proximate increases in body weight/adiposity during the pre-DM period of 
      impaired glucose tolerance. Obesity was, however, essential preceding all NHP 
      cases that developed T2DM.
CI  - Copyright (c) 2013 The Obesity Society.
FAU - Hansen, Barbara C
AU  - Hansen BC
AD  - Obesity, Diabetes and Aging Research Center, College of Medicine, University of 
      South Florida, Tampa, Florida, USA. bchansen@aol.com
FAU - Newcomb, Jennifer D
AU  - Newcomb JD
FAU - Chen, Ren
AU  - Chen R
FAU - Linden, Ellen H
AU  - Linden EH
LA  - eng
GR  - HHSN2532008002C/PHS HHS/United States
GR  - N01AG31012/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130525
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adipose Tissue/physiopathology
MH  - Adiposity
MH  - Animals
MH  - *Body Weight
MH  - Diabetes Mellitus, Type 2/etiology/*physiopathology
MH  - Female
MH  - Glucose Intolerance
MH  - Linear Models
MH  - Macaca
MH  - Male
MH  - Obesity/complications/*physiopathology
EDAT- 2013/05/29 06:00
MHDA- 2014/03/25 06:00
CRDT- 2013/05/29 06:00
PHST- 2011/07/22 00:00 [received]
PHST- 2012/11/26 00:00 [accepted]
PHST- 2013/05/29 06:00 [entrez]
PHST- 2013/05/29 06:00 [pubmed]
PHST- 2014/03/25 06:00 [medline]
AID - 10.1002/oby.20292 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2013 Aug;21(8):1643-9. doi: 10.1002/oby.20292. Epub 2013 
      May 25.