PMID- 23713253
OWN - NLM
STAT- MEDLINE
DCOM- 20140410
LR  - 20161018
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 33
IP  - 3
DP  - 2013 Mar
TI  - [Effects of shuyu ningxln recipe on the praxiology and the expressions of 
      hippocampal BDNF and trkB of model rats with chronic stress-induced depression].
PG  - 370-5
AB  - OBJECTIVE: To observe the effects of Shuyu Ningxin Recipe (SNR) on the praxiology 
      and the expressions of hippocampal brain-derived neurotrophic factor (BDNF) and 
      its receptor tyrosine kinase B (TrkB) of model rats with chronic stress-induced 
      depression, thus exploring its anti-depression mechanisms. METHODS: Sixty adult 
      SD rats were randomly divided into 6 groups, i.e., the normal control group, the 
      model group, the fluoxetine group, the high dose SNR group, the medium dose SNR 
      group, and the low dose SNR group, 10 in each group. All rats were subjected to 
      establish chronic stress-induced depression model for 21 consecutive days. Except 
      those in the normal control group, rats in the rest groups received gastrogavage 
      from the 22nd day. Mice in the model group were administered with normal saline 
      by gastrogavage. SNR at 25.0, 7.5, and 2.5 g/kg was respectively administered to 
      rats in the high dose SNR group, the medium dose SNR group, and the low dose SNR 
      group by gastrogavage. Fluoxetine suspension (12 mg/kg) was given to rats in the 
      fluoxetine group by gastro-gavage. All medication lasted for 3 successive weeks. 
      The weight, open-field test, and the immobility time in forced swimming test were 
      determined before modeling, 3 weeks (after successful modeling), and 6 weeks (by 
      the end of medication). The expressions of hippocampal BDNF and TrkB were 
      measured after the brain tissues were drawn by the end of the experiment. 
      RESULTS: Compared with the normal control group, the body weight grew slowly, the 
      behavior index decreased, the immobility time in forced swimming test was 
      prolonged, and the expressions of BDNF and TrkB were weaken in the model group (P 
      <0.05, P <0.01).The body weight increased, the behavior was improved, the 
      immobility time in forced swimming test was shortened, and the expressions of 
      BDNF and TrkB were enhanced in the high dose SNR group and the fluoxetine group 
      by the and of medication, showing statistical difference when compared with the 
      model group (P <0.05, P <0.01). CONCLUSION: SNR could exert anti-depression by 
      improving the expression levels of hippocampal BDNF and TrkB.
FAU - Sun, Zhi-gao
AU  - Sun ZG
AD  - Department of Chinese Medical Acupuncture, Hainan Branch, the PLA General 
      Hospital, Hainan 572013, China.
FAU - Huang, Quan-zhi
AU  - Huang QZ
FAU - Xu, Cheng-yong
AU  - Xu CY
FAU - Chen, Li-ping
AU  - Chen LP
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Drugs, Chinese Herbal)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/*metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*metabolism
MH  - Stress, Psychological/*metabolism
EDAT- 2013/05/30 06:00
MHDA- 2014/04/11 06:00
CRDT- 2013/05/30 06:00
PHST- 2013/05/30 06:00 [entrez]
PHST- 2013/05/30 06:00 [pubmed]
PHST- 2014/04/11 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Mar;33(3):370-5.