PMID- 23713290
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20171116
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 38
IP  - 4
DP  - 2013 Feb
TI  - [Analgesic effect of sinomenine on SSNI model rats and monoamine 
      neurotransmitters in striatal extracellular fluid].
PG  - 597-604
AB  - OBJECTIVE: To observe the analgesic effect of sinomenine on the neuropathic pain 
      rat model induced by SSNI, and discuss its impact on monoamine neurotransmitters 
      in striatal extracellular fluid. METHOD: Male SD rats were randomly divided into 
      the sham operation group, the SSNI model group, the gabapentin group (100 mg x 
      kg(-1)), the sinomenine high dose group (40 mg x kg(-1)) and the sinomenine low 
      dose group (20 mg x kg(-1)). Mechanical hyperalgesia and cold pain sensitivity 
      were evaluated by Von Frey hairs and cold spray. Striatum was sampled by 
      microdialysis. High performance liquid chromatography-electrochemical detector 
      (HPLC-ECD) were used to detect the content of such neurotransmitters as monoamine 
      neurotransmitters noradrenaline (NE), dopamine (DA), 5-hydroxy tryptamine (5-HT) 
      and their metabolites dihydroxyphenylacetic phenylacetic acid (DOPAC) and 
      5-hydroxyindoleacetic acid (5-HIAA). RESULT: SSNI model rats showed significant 
      improvement in mechanical withdrawal threshold and cold pain sensitivity, 
      significant decrease in intracerebral NE and notable increase in DA, 5-HT and 
      their metabolites. Compared with the model group, the sinomenine high dose group 
      showed significant increase in mechanical withdrawal threshold at 60, 90, 180 and 
      240 min after abdominal administration (P < 0.01), significant decrease in cold 
      pain sensitivity score during 30-240 min (P < 0.05). Sinomenine can significantly 
      up-regulated NE content in striatal extracellular fluid during 45-135 min (P < 
      0.05), remarkably reduce DA content and DOPAC at 45, 75 and 135 min (P < 0.05), 
      5-HT content during 45-135 min, DOPAC during 75-165 min (P < 0.05), and 5-HIAA 
      during 45-135 min (P < 0.05). CONCLUSION: Sinomenine has the intervention effect 
      on neuropathic pain in SSNI model rats. Its mechanism may be related to disorder 
      of monoamine neurotransmitters in striatal extracellular fluid.
FAU - Zhang, Mei-Yu
AU  - Zhang MY
AD  - Experimental Research Center, China Academy of Traditional Chinese Medicine, 
      Beijing 100700, China. meiyu96@126.com
FAU - Li, Peng
AU  - Li P
FAU - Wang, Dan-Qiao
AU  - Wang DQ
FAU - Niu, Xiao-Hong
AU  - Niu XH
FAU - Wang, Ye
AU  - Wang Y
FAU - Wang, Zhi-Guo
AU  - Wang ZG
FAU - Zhang, Ying
AU  - Zhang Y
FAU - Xu, Shi
AU  - Xu S
FAU - Xu, Xiao-Jun
AU  - Xu XJ
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Analgesics)
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Morphinans)
RN  - 0 (Neurotransmitter Agents)
RN  - 63LT81K70N (sinomenine)
SB  - IM
MH  - Analgesics/pharmacology
MH  - Animals
MH  - Biogenic Monoamines/*metabolism
MH  - Disease Models, Animal
MH  - Extracellular Fluid/*drug effects
MH  - Male
MH  - Morphinans/*pharmacology
MH  - Neostriatum/*pathology
MH  - Neurotransmitter Agents/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sciatic Nerve/*drug effects/*injuries/metabolism/pathology
EDAT- 2013/05/30 06:00
MHDA- 2013/06/21 06:00
CRDT- 2013/05/30 06:00
PHST- 2013/05/30 06:00 [entrez]
PHST- 2013/05/30 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2013 Feb;38(4):597-604.