PMID- 23713294
OWN - NLM
STAT- MEDLINE
DCOM- 20130620
LR  - 20130529
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 38
IP  - 4
DP  - 2013 Feb
TI  - [Effect of wuhuang tangkangling on cytokine in patients with type 2 diabetes 
      mellitus].
PG  - 622-4
AB  - OBJECTIVE: To investigate the effects of Wuhuang Tangkangling on tumor necrosis 
      factor-alpha (TNF-alpha), interleukin-6 (IL-6) and high-sensitivity C-reactive 
      protein (hs-CRP) in serum of patients with type 2 diabetes mellitus (T2DM). 
      METHOD: One hundred cases of type 2 diabetes mellitus patients were randomly 
      divided into two groups. The control group was treated with pioglitazone (15 mg x 
      d(-1)) orally once a day in the morning, combined with insulin subcutaneous 
      injection based on blood glucose level. The treatment group was treated with 
      decoction of Wuhuang Tangkang Ling daily, 8 weeks as a course. TNF-alpha, IL-6, 
      hs-CRP, fasting blood glucose (FBG) and postprandial blood glucose (PBG) were 
      tested for two groups of patients before and after the treatment And other 50 
      healthy cases were tested for comparison. RESULT: Before treatment, the level of 
      cytokine, FBG and PBG in the serum of patients with T2DM were significantly 
      higher than healthy cases (P < 0.01). In treatment group, difference between 
      before and after the treatment had statistical significance (P < 0.01); after 
      treatment, difference between treatment group and control group had statistical 
      significance (P < 0.01). CONCLUSION: Wuhuang Tangkangling could significantly 
      decrease the level of TNF-alpha, IL-6, hs-CRP, FBG and PBG in patients with T2DM, 
      and could decrease blood glucose, anti inflammatory, and improve insulin 
      resistance. According to testing these cytokines, a new criteria for evaluating 
      the progress of T2DM and the treatment may be approached.
FAU - Hua, Zhao-Quan
AU  - Hua ZQ
AD  - The First Hospital of Manchuria, Manchuria 021400, China.
FAU - Chang, Yi-Jie
AU  - Chang YJ
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein/metabolism
MH  - Diabetes Mellitus, Type 2/*blood/*drug therapy
MH  - Drugs, Chinese Herbal/*pharmacology/therapeutic use
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2013/05/30 06:00
MHDA- 2013/06/21 06:00
CRDT- 2013/05/30 06:00
PHST- 2013/05/30 06:00 [entrez]
PHST- 2013/05/30 06:00 [pubmed]
PHST- 2013/06/21 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2013 Feb;38(4):622-4.