PMID- 23715774
OWN - NLM
STAT- MEDLINE
DCOM- 20140122
LR  - 20220318
IS  - 1479-683X (Electronic)
IS  - 0804-4643 (Linking)
VI  - 169
IP  - 2
DP  - 2013 Aug
TI  - Body iron stores and the risk of type 2 diabetes in middle-aged men.
PG  - 247-53
LID - 10.1530/EJE-13-0145 [doi]
AB  - OBJECTIVE: We investigated the risk of type 2 diabetes mellitus (T2DM) over a 
      wide range of body iron stores. METHODS: Prospective cohort of 1613 men in the 
      Kuopio Ischemic Heart Disease Risk Factor study, aged 42-60 years, free of T2DM 
      and hereditary hemochromatosis at baseline in 1984-1989. Baseline serum ferritin 
      (sF) and serum-soluble transferrin receptor (sTfR) concentrations were used to 
      predict incident T2DM. T2DM was assessed by questionnaires, blood glucose 
      measurements, and medication reimbursement register. RESULTS: There were 331 
      cases of incident T2DM during the mean follow-up of 16.8 years (27,098 
      person-years). At baseline, subjects who later developed T2DM had average sF 
      concentrations of 191 mug/l (S.D. 155) vs 151 mug/l (S.D. 119) among those who 
      remained healthy, P<0.001. In a multivariate-adjusted logistic regression, each 
      100 mug/l increase in sF corresponded to an average of 14% increased (odds 
      ratio=1.14, 95% CI 1.03-1.26, P=0.009) risk of developing T2DM. In a Cox 
      regression, a markedly increased risk of developing T2DM was observed from the 
      fourth sF quintile (185 mug/l, the median) upward (hazard ratio (HR) first vs 
      fifth quintile=1.5, 95% CI 1.0-2.2, P-trend=0.05). In a corresponding Cox model 
      in sTfR, the subjects in the third quintile (1840 mug/l, the median) had the least 
      risk (HR=0.63, 95% CI 0.42-0.97, P=0.04). CONCLUSIONS: Body iron within the sF 
      reference range is not an important determinant of T2DM risk, whereas high normal 
      and above is associated with markedly increased risk. Iron depletion toward iron 
      deficiency as assessed by sTfR is not protective against T2DM. A rule of thumb 
      safe range could be 30-200 mug/l of sF.
FAU - Aregbesola, Alex
AU  - Aregbesola A
AD  - Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 
      Yliopistonranta 1C, PO Box 1627, FI70211 Kuopio, Finland. alex.aregbesola@uef.fi
FAU - Voutilainen, Sari
AU  - Voutilainen S
FAU - Virtanen, Jyrki K
AU  - Virtanen JK
FAU - Mursu, Jaakko
AU  - Mursu J
FAU - Tuomainen, Tomi-Pekka
AU  - Tuomainen TP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130713
PL  - England
TA  - Eur J Endocrinol
JT  - European journal of endocrinology
JID - 9423848
RN  - 0 (Blood Glucose)
RN  - 0 (Receptors, Transferrin)
RN  - 9007-73-2 (Ferritins)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology
MH  - Ferritins/*blood
MH  - Finland/epidemiology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Receptors, Transferrin/*blood
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2013/05/30 06:00
MHDA- 2014/01/23 06:00
CRDT- 2013/05/30 06:00
PHST- 2013/05/30 06:00 [entrez]
PHST- 2013/05/30 06:00 [pubmed]
PHST- 2014/01/23 06:00 [medline]
AID - EJE-13-0145 [pii]
AID - 10.1530/EJE-13-0145 [doi]
PST - epublish
SO  - Eur J Endocrinol. 2013 Jul 13;169(2):247-53. doi: 10.1530/EJE-13-0145. Print 2013 
      Aug.