PMID- 23716639
OWN - NLM
STAT- MEDLINE
DCOM- 20131104
LR  - 20211021
IS  - 1362-4962 (Electronic)
IS  - 0305-1048 (Print)
IS  - 0305-1048 (Linking)
VI  - 41
IP  - 14
DP  - 2013 Aug
TI  - Transcriptional cross talk between orphan nuclear receptor ERRgamma and transmembrane 
      transcription factor ATF6alpha coordinates endoplasmic reticulum stress response.
PG  - 6960-74
LID - 10.1093/nar/gkt429 [doi]
AB  - Orphan nuclear receptor ERRgamma is a member of nuclear receptor superfamily that 
      regulates several important cellular processes including hepatic glucose and 
      alcohol metabolism. However, mechanistic understanding of transcriptional 
      regulation of the ERRgamma gene remains to be elucidated. Here, we report that 
      activating transcription factor 6alpha (ATF6alpha), an endoplasmic reticulum 
      (ER)-membrane-bound basic leucine zipper (bZip) transcription factor, directly 
      regulates ERRgamma gene expression in response to ER stress. ATF6alpha binds to ATF6alpha 
      responsive element in the ERRgamma promoter. The transcriptional coactivator 
      peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) is 
      required for this transactivation. Chromatin immunoprecipitation (ChIP) assay 
      confirmed the binding of both ATF6alpha and PGC1alpha on the ERRgamma promoter. ChIP assay 
      demonstrated histone H3 and H4 acetylation occurs at the ATF6alpha and PGC1alpha binding 
      site. Of interest, ERRgamma along with PGC1alpha induce ATF6alpha gene transcription upon ER 
      stress. ERRgamma binds to an ERRgamma responsive element in the ATF6alpha promoter. ChIP 
      assay confirmed that both ERRgamma and PGC1alpha bind to a site in the ATF6alpha promoter 
      that exhibits histone H3 and H4 acetylation. Overall, for the first time our data 
      show a novel pathway of cross talk between nuclear receptors and 
      ER-membrane-bound transcription factors and suggest a positive feed-forward loop 
      regulates ERRgamma and ATF6alpha gene transcription.
FAU - Misra, Jagannath
AU  - Misra J
AD  - Center for Nuclear Receptor Signals, Hormone Research Center, School of 
      Biological Science and Technology, Chonnam National University, Gwangju 500-757, 
      Republic of Korea.
FAU - Kim, Don-Kyu
AU  - Kim DK
FAU - Choi, Woogyun
AU  - Choi W
FAU - Koo, Seung-Hoi
AU  - Koo SH
FAU - Lee, Chul-Ho
AU  - Lee CH
FAU - Back, Sung-Hoon
AU  - Back SH
FAU - Kaufman, Randal J
AU  - Kaufman RJ
FAU - Choi, Hueng-Sik
AU  - Choi HS
LA  - eng
GR  - DK088227/DK/NIDDK NIH HHS/United States
GR  - DK042394/DK/NIDDK NIH HHS/United States
GR  - DK093074/DK/NIDDK NIH HHS/United States
GR  - HL052173/HL/NHLBI NIH HHS/United States
GR  - HL057346R01/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130528
PL  - England
TA  - Nucleic Acids Res
JT  - Nucleic acids research
JID - 0411011
RN  - 0 (Activating Transcription Factor 6)
RN  - 0 (Atf6 protein, mouse)
RN  - 0 (ESRRG protein, human)
RN  - 0 (Esrrg protein, mouse)
RN  - 0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
RN  - 0 (Ppargc1a protein, mouse)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Activating Transcription Factor 6/biosynthesis/genetics/*metabolism
MH  - Animals
MH  - Cell Line
MH  - Endoplasmic Reticulum Stress/*genetics
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
MH  - Receptors, Estrogen/biosynthesis/genetics/*metabolism
MH  - Response Elements
MH  - Transcription Factors/metabolism
MH  - *Transcriptional Activation
PMC - PMC3737538
EDAT- 2013/05/30 06:00
MHDA- 2013/11/05 06:00
PMCR- 2013/05/28
CRDT- 2013/05/30 06:00
PHST- 2013/05/30 06:00 [entrez]
PHST- 2013/05/30 06:00 [pubmed]
PHST- 2013/11/05 06:00 [medline]
PHST- 2013/05/28 00:00 [pmc-release]
AID - gkt429 [pii]
AID - 10.1093/nar/gkt429 [doi]
PST - ppublish
SO  - Nucleic Acids Res. 2013 Aug;41(14):6960-74. doi: 10.1093/nar/gkt429. Epub 2013 
      May 28.