PMID- 23716995
OWN - NLM
STAT- MEDLINE
DCOM- 20131213
LR  - 20220316
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 19
IP  - 20
DP  - 2013 May 28
TI  - Nonalcoholic fatty liver disease and microvascular complications in type 2 
      diabetes.
PG  - 3134-42
LID - 10.3748/wjg.v19.i20.3134 [doi]
AB  - AIM: To evaluate the correlation between nonalcoholic fatty liver disease (NAFLD) 
      and microvascular complications in type 2 diabetes mellitus (T2DM). METHODS: Data 
      were obtained from 1217 inpatients with T2DM (757 females, 460 males; aged 63.39 
      +/- 12.28 years). NAFLD was diagnosed by hepatic ultrasonography. Diabetic 
      nephropathy (DN), diabetic peripheral neuropathy (DPN), and diabetic retinopathy 
      (DR) were diagnosed according to their respective criteria. The prevalence of 
      NAFLD and the independent correlations of clinical characteristics with NAFLD 
      were determined by cross-tabulation and logistic regression, respectively. 
      RESULTS: Approximately 61% of inpatients with T2DM in Qingdao, China had NAFLD, 
      which decreased significantly with increase in age and prolonged course of 
      diabetes. The prevalence of NAFLD in patients presenting with DN, DPN and DR was 
      49.4%, 57.2% and 54.9%, respectively. These rates were significantly lower than 
      those of patients without DN, DPN and DR (65.9%, 65.6% and 66.1%, respectively, P 
      < 0.05). Participants with NAFLD had greater body weight, waist circumference 
      (WC), body mass index (BMI), fasting blood glucose (FBG), hemoglobin A1c, alanine 
      aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, blood 
      pressure, as well as triglyceride (TG) levels and lower high-density lipoprotein 
      (HDL) concentration than those without NAFLD (P < 0.05). NAFLD was positively 
      correlated with BMI, WC, TG, FBG, diastolic blood pressure, and systolic blood 
      pressure but negatively correlated with the duration of diabetes, DR, DPN, DN, 
      and HDL. CONCLUSION: Despite the benign nature of NAFLD, efforts should be 
      directed toward early diagnosis, intensive blood glucose and blood pressure 
      control, and effective dyslipidemia correction.
FAU - Lv, Wen-Shan
AU  - Lv WS
AD  - Department of Internal Medicine, the Affiliated Hospital of Medical College, 
      Qingdao University, Qingdao 266100, Shandong Province, China.
FAU - Sun, Rui-Xia
AU  - Sun RX
FAU - Gao, Yan-Yan
AU  - Gao YY
FAU - Wen, Jun-Ping
AU  - Wen JP
FAU - Pan, Rong-Fang
AU  - Pan RF
FAU - Li, Li
AU  - Li L
FAU - Wang, Jing
AU  - Wang J
FAU - Xian, Yu-Xin
AU  - Xian YX
FAU - Cao, Cai-Xia
AU  - Cao CX
FAU - Zheng, Ming
AU  - Zheng M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
SB  - IM
MH  - Aged
MH  - Chi-Square Distribution
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/diagnosis/*epidemiology/physiopathology
MH  - Diabetic Angiopathies/diagnosis/*epidemiology/physiopathology
MH  - Diabetic Nephropathies/epidemiology
MH  - Diabetic Retinopathy/epidemiology
MH  - Dyslipidemias/epidemiology
MH  - Fatty Liver/diagnostic imaging/*epidemiology
MH  - Female
MH  - Humans
MH  - Hypertension/epidemiology
MH  - Logistic Models
MH  - Male
MH  - *Microcirculation
MH  - Middle Aged
MH  - Non-alcoholic Fatty Liver Disease
MH  - Obesity/epidemiology
MH  - Odds Ratio
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - Risk Factors
MH  - Ultrasonography
PMC - PMC3662955
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - Diabetic neuropathy
OT  - Diabetic retinopathy
OT  - Nonalcoholic fatty liver disease
OT  - Type 2 diabetes mellitus
EDAT- 2013/05/30 06:00
MHDA- 2013/12/18 06:00
PMCR- 2013/05/28
CRDT- 2013/05/30 06:00
PHST- 2012/11/28 00:00 [received]
PHST- 2013/03/06 00:00 [revised]
PHST- 2013/03/23 00:00 [accepted]
PHST- 2013/05/30 06:00 [entrez]
PHST- 2013/05/30 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
PHST- 2013/05/28 00:00 [pmc-release]
AID - 10.3748/wjg.v19.i20.3134 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2013 May 28;19(20):3134-42. doi: 10.3748/wjg.v19.i20.3134.