PMID- 23718186
OWN - NLM
STAT- MEDLINE
DCOM- 20140310
LR  - 20161020
IS  - 1768-322X (Electronic)
IS  - 0248-4900 (Linking)
VI  - 105
IP  - 9
DP  - 2013 Sep
TI  - Regulation of connexin- and pannexin-based channels by post-translational 
      modifications.
PG  - 373-98
LID - 10.1111/boc.201200096 [doi]
AB  - Connexin (Cx) and pannexin (Panx) proteins form large conductance channels, which 
      function as regulators of communication between neighbouring cells via gap 
      junctions and/or hemichannels. Intercellular communication is essential to 
      coordinate cellular responses in tissues and organs, thereby fulfilling an 
      essential role in the spreading of signalling, survival and death processes. The 
      functional properties of gap junctions and hemichannels are modulated by 
      different physiological and pathophysiological stimuli. At the molecular level, 
      Cxs and Panxs function as multi-protein channel complexes, regulating their 
      channel localisation and activity. In addition to this, gap junctional channels 
      and hemichannels are modulated by different post-translational modifications 
      (PTMs), including phosphorylation, glycosylation, proteolysis, N-acetylation, 
      S-nitrosylation, ubiquitination, lipidation, hydroxylation, methylation and 
      deamidation. These PTMs influence almost all aspects of communicating junctional 
      channels in normal cell biology and pathophysiology. In this review, we will 
      provide a systematic overview of PTMs of communicating junction proteins and 
      discuss their effects on Cx and Panx-channel activity and localisation.
CI  - (c) 2013 Societe Francaise des Microscopies and Societe de Biologie Cellulaire de 
      France. Published by John Wiley & Sons Ltd.
FAU - D'hondt, Catheleyne
AU  - D'hondt C
AD  - Laboratory of Molecular and Cellular Signalling, Department Cellular and 
      Molecular Medicine, KU Leuven, Campus Gasthuisberg O/N 1, BE-3000, Leuven, 
      Belgium. catheleyne.dhondt@med.kuleuven.be
FAU - Iyyathurai, Jegan
AU  - Iyyathurai J
FAU - Vinken, Mathieu
AU  - Vinken M
FAU - Rogiers, Vera
AU  - Rogiers V
FAU - Leybaert, Luc
AU  - Leybaert L
FAU - Himpens, Bernard
AU  - Himpens B
FAU - Bultynck, Geert
AU  - Bultynck G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20130717
PL  - England
TA  - Biol Cell
JT  - Biology of the cell
JID - 8108529
RN  - 0 (Connexins)
RN  - 0 (Protein Isoforms)
SB  - IM
MH  - Acetylation
MH  - Animals
MH  - Biological Transport
MH  - Cell Communication/genetics
MH  - Connexins/classification/genetics/*metabolism
MH  - Gap Junctions/genetics/*metabolism/ultrastructure
MH  - *Gene Expression Regulation
MH  - Glycosylation
MH  - Humans
MH  - Hydroxylation
MH  - Methylation
MH  - Phosphorylation
MH  - Protein Isoforms/classification/genetics/metabolism
MH  - *Protein Processing, Post-Translational
MH  - Signal Transduction
MH  - Ubiquitination
OTO - NOTNLM
OT  - Connexin
OT  - Gap junctions
OT  - Hemichannels
OT  - Pannexin
OT  - Post-translational modification
EDAT- 2013/05/31 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/05/31 06:00
PHST- 2013/05/17 00:00 [received]
PHST- 2013/05/24 00:00 [accepted]
PHST- 2013/05/31 06:00 [entrez]
PHST- 2013/05/31 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - 10.1111/boc.201200096 [doi]
PST - ppublish
SO  - Biol Cell. 2013 Sep;105(9):373-98. doi: 10.1111/boc.201200096. Epub 2013 Jul 17.