PMID- 23718733
OWN - NLM
STAT- MEDLINE
DCOM- 20140127
LR  - 20181202
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 82
IP  - 2
DP  - 2013 Aug
TI  - Algorithms for the determination of unacceptable HLA antigen mismatches in kidney 
      transplant recipients.
PG  - 83-92
LID - 10.1111/tan.12137 [doi]
AB  - One of the major tasks of human leukocyte antigen (HLA) laboratories is the 
      pretransplant determination of unacceptable HLA antigen mismatches (UAM) in organ 
      transplant recipients. HLA antigen specificities are determined against which the 
      patient has circulating alloantibodies that are expected to harm the transplanted 
      organ. Using the information on UAM, negative crossmatch (XM) prediction or 
      'virtual XM' is possible when a potential donor's complete HLA typing is 
      available. Before the introduction of solid-phase antibody detection assays, UAM 
      were determined using the complement-dependent cytotoxicity methodology. After 
      the introduction of the single antigen bead technique, however, various UAM 
      determination algorithms have emerged. In this report, six different laboratories 
      worldwide present how they determine UAM in their collective of kidney transplant 
      recipients in the pretransplant phase and proceed thereafter to transplantation.
CI  - (c) 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Susal, C
AU  - Susal C
AD  - Department of Transplantation Immunology, Institute of Immunology, University of 
      Heidelberg, Heidelberg, Germany. caner.suesal@med.uni-heidelberg.de
FAU - Roelen, D L
AU  - Roelen DL
FAU - Fischer, G
AU  - Fischer G
FAU - Campos, E F
AU  - Campos EF
FAU - Gerbase-DeLima, M
AU  - Gerbase-DeLima M
FAU - Honger, G
AU  - Honger G
FAU - Schaub, S
AU  - Schaub S
FAU - Lachmann, N
AU  - Lachmann N
FAU - Martorell, J
AU  - Martorell J
FAU - Claas, F
AU  - Claas F
LA  - eng
PT  - Journal Article
DEP - 20130530
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - *Algorithms
MH  - Decision Trees
MH  - Graft Rejection/immunology/*prevention & control
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing/*methods/statistics & numerical data
MH  - Humans
MH  - Isoantibodies/immunology
MH  - Kidney/immunology/pathology
MH  - *Kidney Transplantation
MH  - Unrelated Donors/statistics & numerical data
OTO - NOTNLM
OT  - HLA antibodies
OT  - antibody screening
OT  - kidney transplantation
OT  - unacceptable HLA antigen mismatches
OT  - virtual crossmatch
EDAT- 2013/05/31 06:00
MHDA- 2014/01/28 06:00
CRDT- 2013/05/31 06:00
PHST- 2013/05/31 06:00 [entrez]
PHST- 2013/05/31 06:00 [pubmed]
PHST- 2014/01/28 06:00 [medline]
AID - 10.1111/tan.12137 [doi]
PST - ppublish
SO  - Tissue Antigens. 2013 Aug;82(2):83-92. doi: 10.1111/tan.12137. Epub 2013 May 30.