PMID- 23719424 OWN - NLM STAT- MEDLINE DCOM- 20150305 LR - 20220317 IS - 1875-8622 (Electronic) IS - 1386-0291 (Linking) VI - 56 IP - 4 DP - 2014 TI - Association of red blood cell distribution width, inflammation markers and morphological as well as rheological erythrocyte parameters with target organ damage in hypertension. PG - 325-35 LID - 10.3233/CH-131745 [doi] AB - OBJECTIVES: To assess the relationships of red blood cell distribution width (RDW), mean corpuscular hemoglobin concentration (MCHC) and erythrocyte deformability with pathological changes of selected target organs, and with inflammation markers interleukin-6 (IL-6) and fibrinogen, in a group of newly diagnosed, never-treated and otherwise healthy hypertensive patients. METHODS: The study group consisted of 101 adults divided into three sub-groups: 37 diagnosed arterial hypertension, 29 with hypercholesterolemia, and 35 healthy. The individuals with hypertension or hypercholesterolemia were otherwise healthy and were not on any therapy prior to entering the study. For each individual, data were obtained on: systolic and diastolic blood pressure (SBP, DBP), pulse wave velocity (PWV), carotid intima media thickness (IMT), left ventricle geometry, blood morphology, lipids profile, fibrinogen, CRP, IL-6 and red blood cell deformability index (DI). RESULTS: In the group of hypertensives, the multivariate regression analysis showed significant relationship of RDW with PWV, IL6 and fibrinogen. Also, RDW was found to be correlated with MCHC and DI, and MCHC was significantly related to IMT and IL-6. CONCLUSIONS: A hypothesis has been formulated that the development of target organ damage in hypertension is accompanied by the increasing impairment of erythropoiesis. This process may be mediated by inflammation. FAU - Fornal, Maria AU - Fornal M AD - Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland. FAU - Wizner, Barbara AU - Wizner B AD - Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland. FAU - Cwynar, Marcin AU - Cwynar M AD - Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland. FAU - Krolczyk, Jaroslaw AU - Krolczyk J AD - Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland. FAU - Kwater, Aleksander AU - Kwater A AD - Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland. FAU - Korbut, Renata A AU - Korbut RA AD - Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland. FAU - Grodzicki, Tomasz AU - Grodzicki T AD - Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Krakow, Poland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - Netherlands TA - Clin Hemorheol Microcirc JT - Clinical hemorheology and microcirculation JID - 9709206 RN - 0 (Biomarkers) RN - 0 (Interleukin-6) RN - 9001-32-5 (Fibrinogen) SB - IM MH - Biomarkers/blood MH - Blood Pressure/physiology MH - Erythrocyte Indices MH - Erythrocytes/*pathology MH - Female MH - Fibrinogen/metabolism MH - Humans MH - Hypercholesterolemia/blood/pathology MH - Hypertension/*blood/pathology MH - Inflammation/*blood/pathology MH - Interleukin-6/blood MH - Male MH - Middle Aged OTO - NOTNLM OT - Essential hypertension OT - erythrocyte deformability OT - fibrinogen OT - interleukin-6 OT - mean corpuscular hemoglobin concentration OT - red blood cell distribution width EDAT- 2013/05/31 06:00 MHDA- 2015/03/07 06:00 CRDT- 2013/05/31 06:00 PHST- 2013/05/31 06:00 [entrez] PHST- 2013/05/31 06:00 [pubmed] PHST- 2015/03/07 06:00 [medline] AID - R7M43537L3067410 [pii] AID - 10.3233/CH-131745 [doi] PST - ppublish SO - Clin Hemorheol Microcirc. 2014;56(4):325-35. doi: 10.3233/CH-131745.