PMID- 23719609
OWN - NLM
STAT- MEDLINE
DCOM- 20140117
LR  - 20181202
IS  - 1424-3911 (Electronic)
IS  - 1424-3903 (Linking)
VI  - 13
IP  - 3
DP  - 2013 May-Jun
TI  - Humoral hypercalcemia of malignancy caused by parathyroid hormone-related 
      peptide-secreting neuroendocrine tumors. Report of six cases.
PG  - 324-6
LID - S1424-3903(13)00042-2 [pii]
LID - 10.1016/j.pan.2013.02.007 [doi]
AB  - We report the clinical characteristics and management of six patients with 
      metastatic gastroentero-pancreatic neuroendocrine tumor (NET) presenting with 
      severe hypercalcemia due to elevation of parathyroid hormone-related protein 
      (PTHrP). All patients had histological confirmation of NET, five 
      well-differentiated and one poorly differentiated. In 5 patients, hypercalcemia 
      developed after years after the initial diagnosis of NET. One patient presented 
      with concomitant elevation of PTHrP and intact parathyroid hormone (PTH) in the 
      setting of multiple endocrine neoplasia 1 (MEN1). In all the other cases, PTH 
      levels were low or undetectable. Management of malignant hypercalcemia due to 
      PTHrP-producing NET is challenging, and optimal therapy depends on the extent of 
      metastatic disease and the grade of malignancy. Aggressive tumor cytoreduction in 
      addition to the systemic treatment modalities is frequently used to control 
      disease progression and endocrine symptoms. To our knowledge, this is the largest 
      series to date of hypercalcemia mediated by PTHrP-secreting NET.
CI  - Copyright (c) 2013 IAP and EPC. Published by Elsevier B.V. All rights reserved.
FAU - Milanesi, Anna
AU  - Milanesi A
AD  - Division of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
FAU - Yu, Run
AU  - Yu R
FAU - Wolin, Edward M
AU  - Wolin EM
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130301
PL  - Switzerland
TA  - Pancreatology
JT  - Pancreatology : official journal of the International Association of 
      Pancreatology (IAP) ... [et al.]
JID - 100966936
RN  - 0 (Parathyroid Hormone-Related Protein)
RN  - Humoral Hypercalcemia Of Malignancy
SB  - IM
MH  - Adult
MH  - Combined Modality Therapy
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Hypercalcemia/etiology/*pathology
MH  - Liver Neoplasms/secondary
MH  - Male
MH  - Middle Aged
MH  - Neuroendocrine Tumors/metabolism/*pathology/surgery
MH  - Pancreatic Neoplasms/*pathology/surgery
MH  - Paraneoplastic Syndromes/etiology/*pathology
MH  - Parathyroid Hormone-Related Protein/*metabolism
EDAT- 2013/05/31 06:00
MHDA- 2014/01/18 06:00
CRDT- 2013/05/31 06:00
PHST- 2012/09/27 00:00 [received]
PHST- 2013/02/22 00:00 [revised]
PHST- 2013/02/22 00:00 [accepted]
PHST- 2013/05/31 06:00 [entrez]
PHST- 2013/05/31 06:00 [pubmed]
PHST- 2014/01/18 06:00 [medline]
AID - S1424-3903(13)00042-2 [pii]
AID - 10.1016/j.pan.2013.02.007 [doi]
PST - ppublish
SO  - Pancreatology. 2013 May-Jun;13(3):324-6. doi: 10.1016/j.pan.2013.02.007. Epub 
      2013 Mar 1.