PMID- 23719924
OWN - NLM
STAT- MEDLINE
DCOM- 20131023
LR  - 20190911
IS  - 1880-3989 (Electronic)
IS  - 0388-1350 (Linking)
VI  - 38
IP  - 3
DP  - 2013
TI  - Pulmonary toxicity screening of triclosan in rats after intratracheal 
      instillation.
PG  - 471-5
AB  - Triclosan (TCS) is a chemical compound used in household products as biocide. 
      However, their pulmonary toxicity has been unclear. Thus, the purpose of this 
      study was to investigate the possibility of injury to the lung by inhalation of 
      TCS. Rats were exposed to TCS by single intratracheal instillation of 10 microg/B.W. 
      kg for the low-dose group and 1,000 microg/B.W. kg for the high-dose group, 
      respectively. TCS induced increase in the level of total cell (TC) count, 
      polymorphonuclear leukocytes (PMNs), total protein (TP), lactate acid 
      dehydrogenase (LDH), tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) 
      in bronchoalveolar lavage fluid (BALF) at 1 day after instillation. However, most 
      pulmonary toxicity marker levels except TP in BALF were restored 14 days after 
      instillation. In addition, TCS led to reduction of cell viability with 
      morphological change in lung eptiehelial cells (L2 cell). Therefore, TCS may 
      affect responses of acute inflammation and permeability in the lung.
FAU - Kwon, Jung-Taek
AU  - Kwon JT
AD  - Environmental Health Research Department, National Institute of Environmental 
      Research, Incheon, Korea.
FAU - Yang, Young-Su
AU  - Yang YS
FAU - Kang, Min-Sung
AU  - Kang MS
FAU - Seo, Gyun-Baek
AU  - Seo GB
FAU - Lee, Dong Hun
AU  - Lee DH
FAU - Yang, Mi-Jin
AU  - Yang MJ
FAU - Shim, Ilseob
AU  - Shim I
FAU - Kim, Hyun-Mi
AU  - Kim HM
FAU - Kim, Pilje
AU  - Kim P
FAU - Choi, Kyunghee
AU  - Choi K
FAU - Lee, Kyuhong
AU  - Lee K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - J Toxicol Sci
JT  - The Journal of toxicological sciences
JID - 7805798
RN  - 4NM5039Y5X (Triclosan)
SB  - IM
MH  - Acute Lung Injury/*chemically induced/pathology
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid/chemistry/cytology
MH  - Cell Membrane Permeability
MH  - Cell Survival/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Epithelial Cells/drug effects/pathology
MH  - Household Products
MH  - Instillation, Drug
MH  - Lung/cytology/*drug effects/pathology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Trachea
MH  - Triclosan/*administration & dosage/metabolism/*toxicity
EDAT- 2013/05/31 06:00
MHDA- 2013/10/24 06:00
CRDT- 2013/05/31 06:00
PHST- 2013/05/31 06:00 [entrez]
PHST- 2013/05/31 06:00 [pubmed]
PHST- 2013/10/24 06:00 [medline]
AID - DN/JST.JSTAGE/jts/38.471 [pii]
AID - 10.2131/jts.38.471 [doi]
PST - ppublish
SO  - J Toxicol Sci. 2013;38(3):471-5. doi: 10.2131/jts.38.471.