PMID- 23722324
OWN - NLM
STAT- MEDLINE
DCOM- 20140821
LR  - 20211021
IS  - 1477-0970 (Electronic)
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 20
IP  - 1
DP  - 2014 Jan
TI  - Oligoclonal bands in multiple sclerosis reactive against two herpesviruses and 
      association with magnetic resonance imaging findings.
PG  - 27-34
LID - 10.1177/1352458513490545 [doi]
AB  - BACKGROUND: Two human herpesviruses, human herpesvirus 6 (HHV-6), and 
      Epstein-Barr virus (EBV), have been repeatedly linked to multiple sclerosis (MS). 
      OBJECTIVE: The aim of this study was to investigate HHV-6 and EBV reactive 
      oligoclonal bands (OCBs), and viral DNA in the intrathecal compartment in MS. 
      METHODS: The reactivity of OCBs in cerebrospinal fluid (CSF) for EBV and HHV-6 
      antigens and stability of virus reactive OCBs over time were studied in a 
      well-characterized MS patient cohort. Associations between virus reactive OCBs 
      and viral DNA in CSF (and any clinical and/or radiological findings) were 
      investigated. RESULTS: Of patients with MS, 38% had OCBs reactive to either one 
      of the viruses studied, compared to none in the patients with other inflammatory 
      neurological diseases (p=0.005). The banding pattern of virus reactive OCBs 
      remained the same over time. Furthermore, MS patients with viral DNA in CSF had 
      more contrast enhancing lesions (CELs). CONCLUSION: The stable presence of 
      herpesvirus reactive OCBs in CSF further strengthens the association of MS with 
      these viruses. The finding that herpesviruses might be linked to the appearance 
      of active lesions warrants investigation of new therapeutic strategies to treat 
      these viruses in MS.
FAU - Virtanen, J O
AU  - Virtanen JO
AD  - Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, 
      USA.
FAU - Wohler, J
AU  - Wohler J
FAU - Fenton, K
AU  - Fenton K
FAU - Reich, D S
AU  - Reich DS
FAU - Jacobson, S
AU  - Jacobson S
LA  - eng
GR  - Z01 NS002817-18/Intramural NIH HHS/United States
GR  - Z01 NS002817-19/Intramural NIH HHS/United States
GR  - Z01 NS003040-01/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130530
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (DNA, Viral)
RN  - 0 (Oligoclonal Bands)
SB  - IM
CIN - Mult Scler. 2014 Apr;20(5):638. PMID: 23959710
MH  - Adult
MH  - DNA, Viral/cerebrospinal fluid
MH  - Epstein-Barr Virus Infections/cerebrospinal fluid/*complications
MH  - Female
MH  - Herpesvirus 4, Human
MH  - Herpesvirus 6, Human
MH  - Humans
MH  - Immunoblotting
MH  - Isoelectric Focusing
MH  - Luminescent Measurements
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/cerebrospinal fluid/pathology/*virology
MH  - Oligoclonal Bands/cerebrospinal fluid
MH  - Polymerase Chain Reaction
MH  - Roseolovirus Infections/cerebrospinal fluid/*complications
MH  - Young Adult
PMC - PMC5001156
MID - NIHMS809452
OTO - NOTNLM
OT  - Multiple sclerosis
OT  - immunology
OT  - magnetic resonance imaging
COIS- statement The authors declare that there are no conflicts of interest.
EDAT- 2013/06/01 06:00
MHDA- 2014/08/22 06:00
PMCR- 2016/08/26
CRDT- 2013/06/01 06:00
PHST- 2013/06/01 06:00 [entrez]
PHST- 2013/06/01 06:00 [pubmed]
PHST- 2014/08/22 06:00 [medline]
PHST- 2016/08/26 00:00 [pmc-release]
AID - 1352458513490545 [pii]
AID - 10.1177/1352458513490545 [doi]
PST - ppublish
SO  - Mult Scler. 2014 Jan;20(1):27-34. doi: 10.1177/1352458513490545. Epub 2013 May 
      30.