PMID- 23722357
OWN - NLM
STAT- MEDLINE
DCOM- 20140214
LR  - 20211021
IS  - 1937-5395 (Electronic)
IS  - 1937-5387 (Linking)
VI  - 6
IP  - 4
DP  - 2013 Aug
TI  - Plasma profiles of matrix metalloproteinases and tissue inhibitors of the 
      metalloproteinases predict recurrence of atrial fibrillation following 
      cardioversion.
PG  - 528-35
LID - 10.1007/s12265-013-9471-2 [doi]
AB  - Atrial fibrosis is considered to contribute to atrial fibrillation (AF) 
      recurrence following cardioversion. This study tested the hypothesis that 
      circulating levels of matrix metalloproteinases (MMPs) and tissue inhibitors of 
      MMPs (TIMPs) can predict AF recurrence postcardioversion. Precardioversion plasma 
      samples (n = 82) were assayed for MMPs (eight types), TIMPs (all four types), 
      N-terminus pro B-type natriuretic peptide, and high-sensitivity C-reactive 
      protein levels. Patients were followed for AF recurrence postcardioversion. 
      Despite 100 % restoration of sinus rhythm, 36 (44 %) reverted to AF within 3 
      months. Left atrial volume was increased in patients in whom AF recurred. 
      Precardioversion MMP-9 was higher and TIMP-4 lower with AF recurrence. MMP-9, 
      MMP-3, and TIMP-4 independently predicted AF recurrence. In multivariate 
      analysis, combination of MMP-9, MMP-3, and TIMP-4 increased prediction of AF 
      recurrence. Circulating levels of MMPs and TIMPs predict AF recurrence 
      postcardioversion and may be used in a novel biomarker panel to guide AF 
      stratification and therapy.
FAU - Mukherjee, Rupak
AU  - Mukherjee R
AD  - Division of Cardiothoracic Surgery, Medical University of South Carolina, 770 
      MUSC Complex, Suite 326, Charleston, SC 29425, USA. mukherr@musc.edu
FAU - Akar, Joseph G
AU  - Akar JG
FAU - Wharton, J Marcus
AU  - Wharton JM
FAU - Adams, Deborah K
AU  - Adams DK
FAU - McClure, Catherine D
AU  - McClure CD
FAU - Stroud, Robert E
AU  - Stroud RE
FAU - Rice, Allison D
AU  - Rice AD
FAU - DeSantis, Stacia M
AU  - DeSantis SM
FAU - Spinale, Francis G
AU  - Spinale FG
FAU - Gold, Michael R
AU  - Gold MR
LA  - eng
GR  - HL057952/HL/NHLBI NIH HHS/United States
GR  - HL059165/HL/NHLBI NIH HHS/United States
GR  - HL095608/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130531
PL  - United States
TA  - J Cardiovasc Transl Res
JT  - Journal of cardiovascular translational research
JID - 101468585
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Aged
MH  - Atrial Fibrillation/blood/diagnosis/enzymology/*surgery
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Chi-Square Distribution
MH  - Electric Countershock/*adverse effects
MH  - Fibrosis
MH  - Heart Atria/enzymology/pathology/surgery
MH  - Humans
MH  - Logistic Models
MH  - Matrix Metalloproteinases/*blood
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Predictive Value of Tests
MH  - Recurrence
MH  - Risk Factors
MH  - Time Factors
MH  - Tissue Inhibitor of Metalloproteinases/*blood
MH  - Treatment Outcome
EDAT- 2013/06/01 06:00
MHDA- 2014/02/15 06:00
CRDT- 2013/06/01 06:00
PHST- 2013/03/22 00:00 [received]
PHST- 2013/05/06 00:00 [accepted]
PHST- 2013/06/01 06:00 [entrez]
PHST- 2013/06/01 06:00 [pubmed]
PHST- 2014/02/15 06:00 [medline]
AID - 10.1007/s12265-013-9471-2 [doi]
PST - ppublish
SO  - J Cardiovasc Transl Res. 2013 Aug;6(4):528-35. doi: 10.1007/s12265-013-9471-2. 
      Epub 2013 May 31.