PMID- 23723666
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130603
LR  - 20211021
IS  - 0974-8520 (Print)
IS  - 0976-9382 (Electronic)
IS  - 0974-8520 (Linking)
VI  - 33
IP  - 4
DP  - 2012 Oct
TI  - Effects of turmeric on Alzheimer's disease with behavioral and psychological 
      symptoms of dementia.
PG  - 499-504
LID - 10.4103/0974-8520.110524 [doi]
AB  - We describe here three patients with the Alzheimer's Disease (AD) whose 
      behavioral symptoms were improved remarkably as a result of the turmeric 
      treatment, which is the traditional Indian medicine. Their cognitive decline and 
      Behavioral and Psychological Symptoms of Dementia (BPSD) were very severe. All 
      three patients exhibited irritability, agitation, anxiety, and apathy, two 
      patients suffer from urinary incontinence and wonderings. They were prescribed 
      turmeric powder capsules and started recovering from these symptoms without any 
      adverse reaction in the clinical symptom and laboratory data. After 12 weeks of 
      the treatment, total score of the Neuro-Psychiatric Inventory-brief questionnaire 
      decreased significantly in both acuity of symptoms and burden of caregivers. In 
      one case, the Mini-Mental State Examination (MMSE) score was up five points, from 
      12/30 to 17/30. In the other two cases, no significant change was seen in the 
      MMSE; however, they came to recognize their family within 1 year treatment. All 
      cases have been taking turmeric for more than 1 year, re-exacerbation of BPSD was 
      not seen. The present cases suggest a significant improvement of the behavioral 
      symptoms in the AD with the turmeric treatment, leading to probable benefit of 
      the use of turmeric in individuals with the AD with BPSD.
FAU - Hishikawa, Nozomi
AU  - Hishikawa N
AD  - Chief Physician, Department of Neurology, Kariya Toyota General Hospital, Kariya 
      City, Aichi, Japan.
FAU - Takahashi, Yoriko
AU  - Takahashi Y
FAU - Amakusa, Yoshinobu
AU  - Amakusa Y
FAU - Tanno, Yuhei
AU  - Tanno Y
FAU - Tuji, Yoshitake
AU  - Tuji Y
FAU - Niwa, Hisayoshi
AU  - Niwa H
FAU - Murakami, Nobuyuki
AU  - Murakami N
FAU - Krishna, U K
AU  - Krishna UK
LA  - eng
PT  - Case Reports
PL  - India
TA  - Ayu
JT  - Ayu
JID - 7605807
PMC - PMC3665200
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - behavioral and psychological symptoms of dementia
OT  - curcumin
OT  - mini-mental state examination
OT  - neuropsychiatric inventory-brief questionnaire
OT  - turmeric
EDAT- 2013/06/01 06:00
MHDA- 2013/06/01 06:01
PMCR- 2012/10/01
CRDT- 2013/06/01 06:00
PHST- 2013/06/01 06:00 [entrez]
PHST- 2013/06/01 06:00 [pubmed]
PHST- 2013/06/01 06:01 [medline]
PHST- 2012/10/01 00:00 [pmc-release]
AID - AYU-33-499 [pii]
AID - 10.4103/0974-8520.110524 [doi]
PST - ppublish
SO  - Ayu. 2012 Oct;33(4):499-504. doi: 10.4103/0974-8520.110524.