PMID- 23725285
OWN - NLM
STAT- MEDLINE
DCOM- 20140113
LR  - 20130603
IS  - 1750-7448 (Electronic)
IS  - 1750-743X (Linking)
VI  - 5
IP  - 6
DP  - 2013 Jun
TI  - Dendritic cells in myelodysplastic syndromes: from pathogenesis to immunotherapy.
PG  - 621-37
LID - 10.2217/imt.13.51 [doi]
AB  - Myelodysplastic syndromes (MDS) are clonal disorders of the hematopoietic stem 
      cell characterized by ineffective hematopoiesis leading to peripheral cytopenias. 
      Different processes are involved in its pathogenesis, such as (epi)genetic 
      alterations and immunological dysfunctions. The nature of immune dysregulation is 
      markedly different between various MDS risk groups. In low-risk MDS, the immune 
      system is in a proinflammatory state, whereas in high-risk disease, 
      immunosuppressive features facilitate expansion of the dysplastic clone and can 
      eventually lead to disease progression to acute myeloid leukemia. Various cell 
      types contribute to dysregulation of immune responses in MDS. Dendritic cells 
      (DCs) are important regulators of immunity. However, the role of DCs in MDS has 
      yet to be elucidated. It has been suggested that impaired DC function can hamper 
      adequate immune responses. This review focuses on the involvement of DCs in 
      immune dysregulation in low- and high-risk MDS and the implications for 
      DC-targeted therapies.
FAU - Kerkhoff, Nathalie
AU  - Kerkhoff N
AD  - Department of Hematology, VU University Medical Center, Cancer Center Amsterdam, 
      Amsterdam, The Netherlands. n.kerkhoff@vumc.nl
FAU - Bontkes, Hetty J
AU  - Bontkes HJ
FAU - Westers, Theresia M
AU  - Westers TM
FAU - de Gruijl, Tanja D
AU  - de Gruijl TD
FAU - Kordasti, Shahram
AU  - Kordasti S
FAU - van de Loosdrecht, Arjan A
AU  - van de Loosdrecht AA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunotherapy
JT  - Immunotherapy
JID - 101485158
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Hematopoietic Stem Cells/pathology
MH  - Humans
MH  - Immunotherapy/*methods
MH  - Myelodysplastic Syndromes/*immunology/*therapy
EDAT- 2013/06/04 06:00
MHDA- 2014/01/15 06:00
CRDT- 2013/06/04 06:00
PHST- 2013/06/04 06:00 [entrez]
PHST- 2013/06/04 06:00 [pubmed]
PHST- 2014/01/15 06:00 [medline]
AID - 10.2217/imt.13.51 [doi]
PST - ppublish
SO  - Immunotherapy. 2013 Jun;5(6):621-37. doi: 10.2217/imt.13.51.